Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis

Jeng Hsien Yen, Wen Chun Tsai, Chung Jen Chen, Chia Hui Lin, Tsan Teng Ou, Chaur Jong Hu, Hong Wen Liu

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

Objectives: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. Methods: The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods. Results: The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls. Conclusion: CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.

原文英語
頁(從 - 到)113-116
頁數4
期刊Immunology Letters
88
發行號2
DOIs
出版狀態已發佈 - 8月 5 2003
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學

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