Current asthma in schoolchildren is related to fungal spores in classrooms

Chi Hsien Chen, H. Jasmine Chao, Chang Chuan Chan, Bing Yu Chen, Yue Leon Guo

研究成果: 雜誌貢獻文章

28 引文 (Scopus)

摘要

BACKGROUND: The presence of visible mold in households is associated with asthma. However, the role of "classroom fungus" in the development of childhood asthma, as well as the fungal species that may lead to asthma, remains controversial. This nationwide school survey was conducted to investigate the correlation between fungal spores in classrooms and asthma in schoolchildren. M ETHODS: From April to May 2011, a cross-sectional survey was conducted to assess allergic/asthmatic conditions in schoolchildren aged 6 to 15 years old in 44 schools across Taiwan. Personal histories and current asthmatic conditions were collected using a modified International Study of Asthma and Allergies in Childhood questionnaire. Fungal spores in classroom were collected using a Burkard Personal Air Sampler and counted under light microscopy. Three-level hierarchical modeling was used to determine the complex correlation between fungal spores in classrooms and childhood asthma. R ESULTS: The survey was completed by 6,346 out of 7,154 parents (88.7%). The prevalences of physician-diagnosed asthma, current asthma, and asthma with symptoms reduced on holidays or weekends (ASROH) were 11.7%, 7.5%, and 3.1%, respectively. The geometric mean spore concentrations of total fungi, Aspergillus/Penicillium , and basidiospores were 2,181, 49, and 318 spores/m3 . Aspergillus/Penicillium and basidiospores were significantly correlated with current asthma and ASROH aft er adjusting for personal and school factors. Of those with current asthma, 41% reported relief of symptoms during weekends. CONCLUSIONS: Classroom Aspergillus/Penicillium and basidiospores are significantly associated with childhood asthma and ASROH. Government health policy should explore environmental interventions for the elimination of fungal spores in classrooms to reduce the prevalence of childhood asthma.
原文英語
頁(從 - 到)123-134
頁數12
期刊Chest
146
發行號1
DOIs
出版狀態已發佈 - 2014

指紋

Fungal Spores
Asthma
Holidays
Penicillium
Aspergillus
Fungi
Spores
Health Policy
Taiwan

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

引用此文

Current asthma in schoolchildren is related to fungal spores in classrooms. / Chen, Chi Hsien; Chao, H. Jasmine; Chan, Chang Chuan; Chen, Bing Yu; Guo, Yue Leon.

於: Chest, 卷 146, 編號 1, 2014, p. 123-134.

研究成果: 雜誌貢獻文章

Chen, Chi Hsien ; Chao, H. Jasmine ; Chan, Chang Chuan ; Chen, Bing Yu ; Guo, Yue Leon. / Current asthma in schoolchildren is related to fungal spores in classrooms. 於: Chest. 2014 ; 卷 146, 編號 1. 頁 123-134.
@article{8db3db14426e47f0980a2289b6496754,
title = "Current asthma in schoolchildren is related to fungal spores in classrooms",
abstract = "BACKGROUND: The presence of visible mold in households is associated with asthma. However, the role of {"}classroom fungus{"} in the development of childhood asthma, as well as the fungal species that may lead to asthma, remains controversial. This nationwide school survey was conducted to investigate the correlation between fungal spores in classrooms and asthma in schoolchildren. M ETHODS: From April to May 2011, a cross-sectional survey was conducted to assess allergic/asthmatic conditions in schoolchildren aged 6 to 15 years old in 44 schools across Taiwan. Personal histories and current asthmatic conditions were collected using a modified International Study of Asthma and Allergies in Childhood questionnaire. Fungal spores in classroom were collected using a Burkard Personal Air Sampler and counted under light microscopy. Three-level hierarchical modeling was used to determine the complex correlation between fungal spores in classrooms and childhood asthma. R ESULTS: The survey was completed by 6,346 out of 7,154 parents (88.7{\%}). The prevalences of physician-diagnosed asthma, current asthma, and asthma with symptoms reduced on holidays or weekends (ASROH) were 11.7{\%}, 7.5{\%}, and 3.1{\%}, respectively. The geometric mean spore concentrations of total fungi, Aspergillus/Penicillium , and basidiospores were 2,181, 49, and 318 spores/m3 . Aspergillus/Penicillium and basidiospores were significantly correlated with current asthma and ASROH aft er adjusting for personal and school factors. Of those with current asthma, 41{\%} reported relief of symptoms during weekends. CONCLUSIONS: Classroom Aspergillus/Penicillium and basidiospores are significantly associated with childhood asthma and ASROH. Government health policy should explore environmental interventions for the elimination of fungal spores in classrooms to reduce the prevalence of childhood asthma.",
author = "Chen, {Chi Hsien} and Chao, {H. Jasmine} and Chan, {Chang Chuan} and Chen, {Bing Yu} and Guo, {Yue Leon}",
year = "2014",
doi = "10.1378/chest.13-2129",
language = "English",
volume = "146",
pages = "123--134",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "1",

}

TY - JOUR

T1 - Current asthma in schoolchildren is related to fungal spores in classrooms

AU - Chen, Chi Hsien

AU - Chao, H. Jasmine

AU - Chan, Chang Chuan

AU - Chen, Bing Yu

AU - Guo, Yue Leon

PY - 2014

Y1 - 2014

N2 - BACKGROUND: The presence of visible mold in households is associated with asthma. However, the role of "classroom fungus" in the development of childhood asthma, as well as the fungal species that may lead to asthma, remains controversial. This nationwide school survey was conducted to investigate the correlation between fungal spores in classrooms and asthma in schoolchildren. M ETHODS: From April to May 2011, a cross-sectional survey was conducted to assess allergic/asthmatic conditions in schoolchildren aged 6 to 15 years old in 44 schools across Taiwan. Personal histories and current asthmatic conditions were collected using a modified International Study of Asthma and Allergies in Childhood questionnaire. Fungal spores in classroom were collected using a Burkard Personal Air Sampler and counted under light microscopy. Three-level hierarchical modeling was used to determine the complex correlation between fungal spores in classrooms and childhood asthma. R ESULTS: The survey was completed by 6,346 out of 7,154 parents (88.7%). The prevalences of physician-diagnosed asthma, current asthma, and asthma with symptoms reduced on holidays or weekends (ASROH) were 11.7%, 7.5%, and 3.1%, respectively. The geometric mean spore concentrations of total fungi, Aspergillus/Penicillium , and basidiospores were 2,181, 49, and 318 spores/m3 . Aspergillus/Penicillium and basidiospores were significantly correlated with current asthma and ASROH aft er adjusting for personal and school factors. Of those with current asthma, 41% reported relief of symptoms during weekends. CONCLUSIONS: Classroom Aspergillus/Penicillium and basidiospores are significantly associated with childhood asthma and ASROH. Government health policy should explore environmental interventions for the elimination of fungal spores in classrooms to reduce the prevalence of childhood asthma.

AB - BACKGROUND: The presence of visible mold in households is associated with asthma. However, the role of "classroom fungus" in the development of childhood asthma, as well as the fungal species that may lead to asthma, remains controversial. This nationwide school survey was conducted to investigate the correlation between fungal spores in classrooms and asthma in schoolchildren. M ETHODS: From April to May 2011, a cross-sectional survey was conducted to assess allergic/asthmatic conditions in schoolchildren aged 6 to 15 years old in 44 schools across Taiwan. Personal histories and current asthmatic conditions were collected using a modified International Study of Asthma and Allergies in Childhood questionnaire. Fungal spores in classroom were collected using a Burkard Personal Air Sampler and counted under light microscopy. Three-level hierarchical modeling was used to determine the complex correlation between fungal spores in classrooms and childhood asthma. R ESULTS: The survey was completed by 6,346 out of 7,154 parents (88.7%). The prevalences of physician-diagnosed asthma, current asthma, and asthma with symptoms reduced on holidays or weekends (ASROH) were 11.7%, 7.5%, and 3.1%, respectively. The geometric mean spore concentrations of total fungi, Aspergillus/Penicillium , and basidiospores were 2,181, 49, and 318 spores/m3 . Aspergillus/Penicillium and basidiospores were significantly correlated with current asthma and ASROH aft er adjusting for personal and school factors. Of those with current asthma, 41% reported relief of symptoms during weekends. CONCLUSIONS: Classroom Aspergillus/Penicillium and basidiospores are significantly associated with childhood asthma and ASROH. Government health policy should explore environmental interventions for the elimination of fungal spores in classrooms to reduce the prevalence of childhood asthma.

UR - http://www.scopus.com/inward/record.url?scp=84903825901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903825901&partnerID=8YFLogxK

U2 - 10.1378/chest.13-2129

DO - 10.1378/chest.13-2129

M3 - Article

C2 - 24676386

AN - SCOPUS:84903825901

VL - 146

SP - 123

EP - 134

JO - Chest

JF - Chest

SN - 0012-3692

IS - 1

ER -