Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis

S. E. Chuang, M. L. Kuo, C. H. Hsu, C. R. Chen, J. K. Lin, G. M. Lai, C. Y. Hsieh, A. L. Cheng

研究成果: 雜誌貢獻文章

213 引文 (Scopus)

摘要

Curcumin has been widely used as a spice and coloring agent in foods. Recently, curcumin was found to possess chemopreventive effects against skin cancer, forestomach cancer, colon cancer and oral cancer in mice. Clinical trials of curcumin for prevention of human cancers are currently ongoing. In this study, we examine the chemopreventive effect of curcumin on murine hepatocarcinogenesis. C3H/HeN mice were injected i.p. with N-diethylnitrosamine (DEN) at the age of 5 weeks. The curcumin group started eating 0.2% curcumin-containing diet 4 days before DEN injection until death. The mice were then serially killed at the scheduled times to examine the development of hepatocellular carcinoma (HCC) and changes in intermediate biological markers. At the age of 42 weeks, the curcumin group, as compared with the control group (DEN alone), had an 81% reduction in multiplicity (0.5 versus 2.57) and a 62% reduction in incidence (38 versus 100%) of development of HCC. A series of intermediate biological markers were examined by western blot. While hepatic tissues obtained from the DEN-treated mice showed a remarkable increase in the levels of p21(ras), PCNA and CDC2 proteins, eating a curcumin-containing diet reversed the levels to normal values. These results indicate that curcumin effectively inhibits DEN-induced hepatocarcinogenesis in the mouse. The underlying mechanisms of the phenomenon and the feasibility of using curcumin in the chemoprevention of human HCC should be further explored.

原文英語
頁(從 - 到)331-335
頁數5
期刊Carcinogenesis
21
發行號2
出版狀態已發佈 - 2000
對外發佈Yes

指紋

Diethylnitrosamine
Curcumin
Diet
Hepatocellular Carcinoma
Mouth Neoplasms
Colonic Neoplasms
Food Coloring Agents
Eating
Biomarkers
Proto-Oncogene Proteins p21(ras)
Spices
Inbred C3H Mouse
Chemoprevention
Proliferating Cell Nuclear Antigen
Skin Neoplasms
Reference Values
Western Blotting
Clinical Trials

ASJC Scopus subject areas

  • Cancer Research

引用此文

Chuang, S. E., Kuo, M. L., Hsu, C. H., Chen, C. R., Lin, J. K., Lai, G. M., ... Cheng, A. L. (2000). Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Carcinogenesis, 21(2), 331-335.

Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. / Chuang, S. E.; Kuo, M. L.; Hsu, C. H.; Chen, C. R.; Lin, J. K.; Lai, G. M.; Hsieh, C. Y.; Cheng, A. L.

於: Carcinogenesis, 卷 21, 編號 2, 2000, p. 331-335.

研究成果: 雜誌貢獻文章

Chuang, SE, Kuo, ML, Hsu, CH, Chen, CR, Lin, JK, Lai, GM, Hsieh, CY & Cheng, AL 2000, 'Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis', Carcinogenesis, 卷 21, 編號 2, 頁 331-335.
Chuang, S. E. ; Kuo, M. L. ; Hsu, C. H. ; Chen, C. R. ; Lin, J. K. ; Lai, G. M. ; Hsieh, C. Y. ; Cheng, A. L. / Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. 於: Carcinogenesis. 2000 ; 卷 21, 編號 2. 頁 331-335.
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