Curcumin and saikosaponin A inhibit chemical-induced liver inflammation and fibrosis in rats

Shu Ju Wu, Ka Wai Tam, Ya Hui Tsai, Chun Chao Chang, Jane C J Chao

研究成果: 雜誌貢獻文章

80 引文 斯高帕斯(Scopus)

摘要

Curcumin and saikosaponin A as antioxidants improve antioxidant status. This study investigated the anti-inflammatory and antifibrotic actions of curcumin and saikosaponin A on CCl4-induced liver damage. Sprague-Dawley rats were randomly divided into control, CCl4, CCl4+ curcumin (0.005%; CU), CCl4 + saikosaponin A (0.004%; SS), and CCl4 + curcumin + saikosaponin A (0.005% + 0.004%; CU + SS) groups. Carbon tetrachloride (40% in olive oil) at a dose of 0.75 ml/kg was injected intraperitoneally once a week. Curcumin and saikosaponin A were supplemented alone or in combination with diet 1 week before CCl4 injection for 8 weeks. After 8-week supplementation, histopathological results showed hepatic collagen deposition was significantly reduced in the CU and SS groups, and activated nuclear factor-κ B expression induced by CCl 4 in the liver was significantly inhibited by curcumin and/or saikosaponin A. Hepatic proinflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6 were significantly inhibited, and anti-inflammatory cytokine interleukin-10 was significantly increased by supplementation with curcumin and/or saikosaponin A. Additionally, curcumin and/or saikosaponin A significantly reduced the increased levels of hepatic transforming growth factor-β1 and hydroxyproline after CCl4 treatment. Therefore, supplementation with curcumin and/or saikosaponin A suppress inflammation and fibrogenesis in rats with CCl4-induced liver injury. However, the combination has no additive effects on anti-inflammation and antifibrosis.

原文英語
頁(從 - 到)99-111
頁數13
期刊American Journal of Chinese Medicine
38
發行號1
DOIs
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • Complementary and alternative medicine

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