Crystal structure of a z-dna fragment containing thymine/2-aminoadenine base pairs

Miguel Coll, Andrew H.J. Wang, Gijs A. Van Der Marel, Jacques H. Van Boom, Alexander Rich

研究成果: 雜誌貢獻文章同行評審

32 引文 斯高帕斯(Scopus)

摘要

The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 Å resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.

原文英語
頁(從 - 到)157-172
頁數16
期刊Journal of Biomolecular Structure and Dynamics
4
發行號2
DOIs
出版狀態已發佈 - 10月 1986
對外發佈

ASJC Scopus subject areas

  • 結構生物學
  • 分子生物學

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