CREB and leukemogenesis

Er Chieh Cho, Bryan Mitton, Kathleen M. Sakamoto

研究成果: 雜誌貢獻回顧型文獻同行評審

43 引文 斯高帕斯(Scopus)

摘要

Acute myeloid leukemia (AML) is one of the most common leukemias with a 20% 5-year event-free survival in adults and 50% overall survival in children, despite aggressive chemotherapy treatment and bone marrow transplantation. The incidence and mortality rates for acute leukemia have only slightly decreased over the last 20 years, and therefore greater understanding of the molecular mechanisms associated with leukemic progression is needed. To this end, a number of transcription factors that appear to play a central role in leukemogenesis are being investigated; among them is the cAMP response element binding protein (CREB). CREB is a transcription factor that can regulate downstream targets involving in various cellular functions including cell proliferation, survival, and differentiation. In several studies, the majority of bone marrow samples from patients with acute lymphoid and myeloid leukemia demonstrate CREB overexpression. Moreover, CREB overexpression is associated with a poor outcome in AML patients. This review summarizes the role of CREB in leukemogenesis.

原文英語
頁(從 - 到)37-46
頁數10
期刊Critical Reviews in Oncogenesis
16
發行號1-2
DOIs
出版狀態已發佈 - 2011
對外發佈

ASJC Scopus subject areas

  • 癌症研究

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