Coupling dichloroacetate treatment with curcumin significantly enhances anticancer potential

Ping Chuan Kan, Yu Jia Chang, Chin Sung Chien, Chen Ying Su, Hsu Wei Fang

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Background/Aim: Dichloroacetate (DCA) and curcumin have been shown to be potent drug candidates in cancer therapy. Our study aimed to investigate the combined effects of DCA and essential oil-blended curcumin (ECUR) using the hepatoma Huh-7 cell model. Materials and Methods: Muse™ Cell Cycle assay, Muse™ Annexin V & Dead Cell assay, Muse™ Oxidative Stress assay, and western blot analysis were applied to explore the underlying mechanisms. Results: DCA combined with ECUR dramatically augmented inhibition of cell survival and enhanced apoptotic induction. The enhanced apoptosis was accompanied by mitochondria-dependent apoptotic signaling activation and corroborated with significant cellular morphological alternations. Conclusion: Apoptosis was the major event contributing to the synergistically boosted antiproliferative effect. Coupling DCA treatment with curcumin may rationally be expected to lower the DCA dose needed and relatively reduce accompanying toxicity and oxidative damage while enhancing anticancer potential. This novel 'add-on' approach is, thus, of enormous value to the current DCA therapy.
原文英語
頁(從 - 到)6253-6261
頁數9
期刊Anticancer Research
38
發行號11
DOIs
出版狀態已發佈 - 十一月 1 2018

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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