Cosmetic applications of selected traditional Chinese herbal medicines

Kuo-Hsien Wang, Rong Dih Lin, Feng-Lin Hsu, Yen-Hua Huang, Hsien Chang Chang, Ching Yi Huang, Mei-Hsien Lee

研究成果: 雜誌貢獻文章

138 引文 (Scopus)

摘要

Because tyrosinase catalyzes melanin synthesis, tyrosinase inhibitors are important in cosmetic skin-whitening. Oxidative stress contributes to skin aging and can adversely affect skin health, which means antioxidants active in skin cells may support skin health. We examined 25 traditional Chinese herbal medicines that might be useful for skin-whitening and skin health. Extracts (100 μg/mL) were tested for cytotoxicity on human epidermal melanocytes (HEMn); 12 exhibited low cytotoxicity. Their effects on tyrosinase and melanin inhibitory activities and free radical scavenging activities were further assessed. Phenolic contents were evaluated using Folin-Ciocalteu reagent. Four herbs, Pharbitis nil, Sophora japonica, Spatholobus suberectus, and Morus alba, exhibited potent inhibitory effects on tyrosinase (IC50 values 24.9, 95.6, 83.9, and 78.3 μg/mL, respectively). Melanin inhibition was not dose-dependent. Sophora japonica (IC50: 14.46 μg/mL, 1,1-diphenyl-2-picrylhydrazyl (DPPH); 1.95 μg/mL, hydroxyl radical) and Spatholobus suberectus (IC50: 10.51 μg/mL, DPPH; 4.36 μg/mL, hydroxyl radical) showed good antioxidative activities and high phenolic contents (255 and 189 mg of gallic acid/g extract, respectively). Among active anti-tyrosinase extracts, Sophora japonica and Spatholobus suberectus were especially potent in HEMn cells in terms of free radical scavenging effects and high phenolic contents, making them the strongest candidates for cosmetic application found in the current study.
原文英語
頁(從 - 到)353-359
頁數7
期刊Journal of Ethnopharmacology
106
發行號3
DOIs
出版狀態已發佈 - 七月 19 2006

指紋

Herbal Medicine
Monophenol Monooxygenase
Cosmetics
Sophora
Skin
Melanins
Inhibitory Concentration 50
Melanocytes
Hydroxyl Radical
Free Radicals
Ipomoea nil
Health
Skin Aging
Morus
Gallic Acid
Oxidative Stress
Antioxidants

ASJC Scopus subject areas

  • Pharmacology

引用此文

Cosmetic applications of selected traditional Chinese herbal medicines. / Wang, Kuo-Hsien; Lin, Rong Dih; Hsu, Feng-Lin; Huang, Yen-Hua; Chang, Hsien Chang; Huang, Ching Yi; Lee, Mei-Hsien.

於: Journal of Ethnopharmacology, 卷 106, 編號 3, 19.07.2006, p. 353-359.

研究成果: 雜誌貢獻文章

Wang, Kuo-Hsien ; Lin, Rong Dih ; Hsu, Feng-Lin ; Huang, Yen-Hua ; Chang, Hsien Chang ; Huang, Ching Yi ; Lee, Mei-Hsien. / Cosmetic applications of selected traditional Chinese herbal medicines. 於: Journal of Ethnopharmacology. 2006 ; 卷 106, 編號 3. 頁 353-359.
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title = "Cosmetic applications of selected traditional Chinese herbal medicines",
abstract = "Because tyrosinase catalyzes melanin synthesis, tyrosinase inhibitors are important in cosmetic skin-whitening. Oxidative stress contributes to skin aging and can adversely affect skin health, which means antioxidants active in skin cells may support skin health. We examined 25 traditional Chinese herbal medicines that might be useful for skin-whitening and skin health. Extracts (100 μg/mL) were tested for cytotoxicity on human epidermal melanocytes (HEMn); 12 exhibited low cytotoxicity. Their effects on tyrosinase and melanin inhibitory activities and free radical scavenging activities were further assessed. Phenolic contents were evaluated using Folin-Ciocalteu reagent. Four herbs, Pharbitis nil, Sophora japonica, Spatholobus suberectus, and Morus alba, exhibited potent inhibitory effects on tyrosinase (IC50 values 24.9, 95.6, 83.9, and 78.3 μg/mL, respectively). Melanin inhibition was not dose-dependent. Sophora japonica (IC50: 14.46 μg/mL, 1,1-diphenyl-2-picrylhydrazyl (DPPH); 1.95 μg/mL, hydroxyl radical) and Spatholobus suberectus (IC50: 10.51 μg/mL, DPPH; 4.36 μg/mL, hydroxyl radical) showed good antioxidative activities and high phenolic contents (255 and 189 mg of gallic acid/g extract, respectively). Among active anti-tyrosinase extracts, Sophora japonica and Spatholobus suberectus were especially potent in HEMn cells in terms of free radical scavenging effects and high phenolic contents, making them the strongest candidates for cosmetic application found in the current study.",
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AU - Wang, Kuo-Hsien

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AU - Hsu, Feng-Lin

AU - Huang, Yen-Hua

AU - Chang, Hsien Chang

AU - Huang, Ching Yi

AU - Lee, Mei-Hsien

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N2 - Because tyrosinase catalyzes melanin synthesis, tyrosinase inhibitors are important in cosmetic skin-whitening. Oxidative stress contributes to skin aging and can adversely affect skin health, which means antioxidants active in skin cells may support skin health. We examined 25 traditional Chinese herbal medicines that might be useful for skin-whitening and skin health. Extracts (100 μg/mL) were tested for cytotoxicity on human epidermal melanocytes (HEMn); 12 exhibited low cytotoxicity. Their effects on tyrosinase and melanin inhibitory activities and free radical scavenging activities were further assessed. Phenolic contents were evaluated using Folin-Ciocalteu reagent. Four herbs, Pharbitis nil, Sophora japonica, Spatholobus suberectus, and Morus alba, exhibited potent inhibitory effects on tyrosinase (IC50 values 24.9, 95.6, 83.9, and 78.3 μg/mL, respectively). Melanin inhibition was not dose-dependent. Sophora japonica (IC50: 14.46 μg/mL, 1,1-diphenyl-2-picrylhydrazyl (DPPH); 1.95 μg/mL, hydroxyl radical) and Spatholobus suberectus (IC50: 10.51 μg/mL, DPPH; 4.36 μg/mL, hydroxyl radical) showed good antioxidative activities and high phenolic contents (255 and 189 mg of gallic acid/g extract, respectively). Among active anti-tyrosinase extracts, Sophora japonica and Spatholobus suberectus were especially potent in HEMn cells in terms of free radical scavenging effects and high phenolic contents, making them the strongest candidates for cosmetic application found in the current study.

AB - Because tyrosinase catalyzes melanin synthesis, tyrosinase inhibitors are important in cosmetic skin-whitening. Oxidative stress contributes to skin aging and can adversely affect skin health, which means antioxidants active in skin cells may support skin health. We examined 25 traditional Chinese herbal medicines that might be useful for skin-whitening and skin health. Extracts (100 μg/mL) were tested for cytotoxicity on human epidermal melanocytes (HEMn); 12 exhibited low cytotoxicity. Their effects on tyrosinase and melanin inhibitory activities and free radical scavenging activities were further assessed. Phenolic contents were evaluated using Folin-Ciocalteu reagent. Four herbs, Pharbitis nil, Sophora japonica, Spatholobus suberectus, and Morus alba, exhibited potent inhibitory effects on tyrosinase (IC50 values 24.9, 95.6, 83.9, and 78.3 μg/mL, respectively). Melanin inhibition was not dose-dependent. Sophora japonica (IC50: 14.46 μg/mL, 1,1-diphenyl-2-picrylhydrazyl (DPPH); 1.95 μg/mL, hydroxyl radical) and Spatholobus suberectus (IC50: 10.51 μg/mL, DPPH; 4.36 μg/mL, hydroxyl radical) showed good antioxidative activities and high phenolic contents (255 and 189 mg of gallic acid/g extract, respectively). Among active anti-tyrosinase extracts, Sophora japonica and Spatholobus suberectus were especially potent in HEMn cells in terms of free radical scavenging effects and high phenolic contents, making them the strongest candidates for cosmetic application found in the current study.

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