Correlation of clinical features and genetic profiles of stromal interaction molecule 1 (STIM1) in colorectal cancers

Henry Sung Ching Wong, Wei Chiao Chang

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

STIM1 overexpression has been observed in a portion of colorectal cancer (CRC) patients and associated with cancer cell invasion and migration. To characterize the distinctive expression profiles associated with stromal interaction molecule 1 (STIM1) overexpression/low-expression between CRC subtypes, and further assess the divergence transcription regulation impact of STIM1 between colon (COADs) and rectum (READs) adenocarcinomas in order to depict the role of SOCE pathway in CRCs, we have conducted a comprehensive phenome-transcriptome-interactome analysis to clarify underlying molecular differences of COADs/READs contributed by STIM1. Results demonstrated that a number of novel STIM1-associated signatures have been identified in COADs but not READs. Specifically, the presence of STIM1 overexpression in COADs, which represented a disturbance of the SOCE pathway, was associated with cell migration and cell motility properties. We identified 11 prognostic mRNA/miRNA predictors associated with the overall survival of COAD patients, suggesting the correlation of STIM1-associated features to clinicopathological outcomes. These findings enhance our understanding on differences between CRC subtypes in panoramic view, and suggested STIM1 as a promising therapeutic biomarker in COADs.

原文英語
頁(從 - 到)42169-42182
頁數14
期刊Oncotarget
6
發行號39
DOIs
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • Oncology

指紋 深入研究「Correlation of clinical features and genetic profiles of stromal interaction molecule 1 (STIM1) in colorectal cancers」主題。共同形成了獨特的指紋。

引用此