Correlation between tumor angiogenesis and metastasis in breast cancer.

J. S. Chu, W. J. Lee, T. C. Chang, K. J. Chang, H. C. Hsu

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

摘要

New vessel formation (angiogenesis) plays an important role in the metastasis of cancer cells. To investigate the correlation between tumor angiogenesis and metastatic potential in breast cancer, the microvessel counts of tumor specimens from 81 women with primary infiltrating ductal carcinomas were examined. Histologic parameters (nodal status, tumor size and tumor grade) and hormone receptor status were also analyzed. We found that axillary node metastasis correlated significantly with the microvessel counts per 200x field and with tumor size, but not with age, tumor grade or hormone receptor status. Tumors without axillary node involvement had a lower microvessel count, irrespective of age, tumor size, tumor grade or hormone receptor status. Logistic regression demonstrated that the microvessel count provided the most important estimate of the relative risk of metastasis. These results suggest that, in invasive breast carcinoma, angiogenesis is closely related to metastatic potential.

原文英語
頁(從 - 到)373-378
頁數6
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
94
發行號7
出版狀態已發佈 - 七月 1995
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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