Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

Tsi S. Huang, Susan Shin-Jung Lee, Hui Z. Tu, Wen Kuei Huang, Yao Shen Chen, Chung K. Huang, Shue R. Wann, Hsi Hsun Lin, Yung Ching Liu

研究成果: 雜誌貢獻文章同行評審

38 引文 斯高帕斯(Scopus)

摘要

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

原文英語
頁(從 - 到)3672-3673
頁數2
期刊Antimicrobial Agents and Chemotherapy
47
發行號11
DOIs
出版狀態已發佈 - 十一月 2003
對外發佈Yes

ASJC Scopus subject areas

  • Pharmacology (medical)

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