Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis

Po Wei Lin, Ren Shyan Liu, Tsan Hon Liou, Li Chern Pan, Chi-Hsien Chen

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.
原文英語
頁(從 - 到)1221-1226
頁數6
期刊Applied Radiation and Isotopes
65
發行號11
DOIs
出版狀態已發佈 - 十一月 2007

指紋

arthritis
rabbits
fluids
interleukins
animals
estimates

ASJC Scopus subject areas

  • Radiation

引用此文

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title = "Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis",
abstract = "The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.",
keywords = "[F]-fluoro-2-deoxyglucose, Arthritis severity, Inflammatory arthritis, Positron emission tomography, Tumor necrosis factor alpha",
author = "Lin, {Po Wei} and Liu, {Ren Shyan} and Liou, {Tsan Hon} and Pan, {Li Chern} and Chi-Hsien Chen",
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T1 - Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration

T2 - A study with two rabbit models of acute inflammatory arthritis

AU - Lin, Po Wei

AU - Liu, Ren Shyan

AU - Liou, Tsan Hon

AU - Pan, Li Chern

AU - Chen, Chi-Hsien

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AB - The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.

KW - [F]-fluoro-2-deoxyglucose

KW - Arthritis severity

KW - Inflammatory arthritis

KW - Positron emission tomography

KW - Tumor necrosis factor alpha

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