Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

Win Ping Deng; Ming Wei Chao; Wen-FuThomas Lai; Chi Sun; Chen Yen Chung; Cheng Chia Wu; I. Hsin Lin; Jeng Jong Hwang; Chih Hsiung Wu; Wen Ta Chiu; Chia Yu Chen; John Leslie Redpath

doi:10.1016/j.canlet.2005.03.031

Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

Win Ping Deng, Ming Wei Chao, Wen-FuThomas Lai, Chi Sun, Chen Yen Chung, Cheng Chia Wu, I. Hsin Lin, Jeng Jong Hwang, Chih Hsiung Wu, Wen Ta Chiu, Chia Yu Chen, John Leslie Redpath

研究成果: 雜誌貢獻 › 文章 › 同行評審

8 引文斯高帕斯（Scopus）

摘要

We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P

原文	英語
頁（從 - 到）	315-327
頁數	13
期刊	Cancer Letters
卷	233
發行號	2
DOIs	https://doi.org/10.1016/j.canlet.2005.03.031
出版狀態	已發佈 - 2月 28 2006

ASJC Scopus subject areas

癌症研究
分子生物學
腫瘤科

UN SDG

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10.1016/j.canlet.2005.03.031

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title = "Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53",

abstract = "We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P",

keywords = "Cancer reversion, HPV, IAP, p53, TCM, Yigan Kang",

author = "Deng, {Win Ping} and Chao, {Ming Wei} and Wen-FuThomas Lai and Chi Sun and Chung, {Chen Yen} and Wu, {Cheng Chia} and Lin, {I. Hsin} and Hwang, {Jeng Jong} and Wu, {Chih Hsiung} and Chiu, {Wen Ta} and Chen, {Chia Yu} and Redpath, {John Leslie}",

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AU - Deng, Win Ping

AU - Chao, Ming Wei

AU - Lai, Wen-FuThomas

AU - Sun, Chi

AU - Chung, Chen Yen

AU - Wu, Cheng Chia

AU - Lin, I. Hsin

AU - Hwang, Jeng Jong

AU - Wu, Chih Hsiung

AU - Chiu, Wen Ta

AU - Chen, Chia Yu

AU - Redpath, John Leslie

PY - 2006/2/28

Y1 - 2006/2/28

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AB - We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P

KW - Cancer reversion

KW - HPV

KW - IAP

KW - p53

KW - TCM

KW - Yigan Kang

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Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

摘要

ASJC Scopus subject areas

UN SDG

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