Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

Win Ping Deng, Ming Wei Chao, Wen-FuThomas Lai, Chi Sun, Chen Yen Chung, Cheng Chia Wu, I. Hsin Lin, Jeng Jong Hwang, Chih Hsiung Wu, Wen Ta Chiu, Chia Yu Chen, John Leslie Redpath

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8 引文 斯高帕斯(Scopus)

摘要

We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P
原文英語
頁(從 - 到)315-327
頁數13
期刊Cancer Letters
233
發行號2
DOIs
出版狀態已發佈 - 二月 28 2006

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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