Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome

Po Ming Wu, Hsin I. Shih, Wen Hao Yu, Li Wen Chen, Lie Chuan Wang, Chao Ching Huang, Yi Fang Tu

研究成果: 雜誌貢獻文章

摘要

Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age.
原文英語
期刊Pediatrics and Neonatology
DOIs
出版狀態接受/付印 - 一月 1 2018

指紋

Corpus Callosum
Premature Infants
Cerebral Palsy
Intellectual Disability
Gestational Age
Body Weight
Periventricular Leukomalacia
Very Low Birth Weight Infant
Growth
Birth Weight
Cerebellar Vermis
Pregnancy
Brain

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

引用此文

Corpus callosum and cerebellar vermis size in very preterm infants : Relationship to long-term neurodevelopmental outcome. / Wu, Po Ming; Shih, Hsin I.; Yu, Wen Hao; Chen, Li Wen; Wang, Lie Chuan; Huang, Chao Ching; Tu, Yi Fang.

於: Pediatrics and Neonatology, 01.01.2018.

研究成果: 雜誌貢獻文章

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title = "Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome",
abstract = "Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age.",
keywords = "cerebellum, cerebral palsy, cranial ultrasound, mental retardation, preterm",
author = "Wu, {Po Ming} and Shih, {Hsin I.} and Yu, {Wen Hao} and Chen, {Li Wen} and Wang, {Lie Chuan} and Huang, {Chao Ching} and Tu, {Yi Fang}",
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publisher = "臺灣兒科醫學會",

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TY - JOUR

T1 - Corpus callosum and cerebellar vermis size in very preterm infants

T2 - Relationship to long-term neurodevelopmental outcome

AU - Wu, Po Ming

AU - Shih, Hsin I.

AU - Yu, Wen Hao

AU - Chen, Li Wen

AU - Wang, Lie Chuan

AU - Huang, Chao Ching

AU - Tu, Yi Fang

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age.

AB - Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age.

KW - cerebellum

KW - cerebral palsy

KW - cranial ultrasound

KW - mental retardation

KW - preterm

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DO - 10.1016/j.pedneo.2018.05.012

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JO - Pediatrics and Neonatology

JF - Pediatrics and Neonatology

SN - 1875-9572

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