Contributions of thyroid hormone to cancer metastasis

Shaker A. Mousa, Gennadi V. Glinsky, Hung Yun Lin, Osnat Ashur-Fabian, Aleck Hercbergs, Kelly A. Keating, Paul J. Davis

研究成果: 雜誌貢獻回顧型文獻同行評審

22 引文 斯高帕斯(Scopus)

摘要

Acting at a cell surface receptor on the extracellular domain of integrin αvβ3, thyroid hormone analogues regulate downstream the expression of a large panel of genes relevant to cancer cell proliferation, to cancer cell survival pathways, and to tumor-linked angiogenesis. Because αvβ is involved in the cancer cell metastatic process, we examine here the possibility that thyroid hormone as L-thyroxine (T4) and the thyroid hormone antagonist, tetraiodothyroacetic acid (tetrac), may respectively promote and inhibit metastasis. Actions of T4 and tetrac that are relevant to cancer metastasis include the multitude of synergistic effects on molecular levels such as expression of matrix metalloproteinase genes, angiogenesis support genes, receptor tyrosine kinase (EGFR/ERBB2) genes, specific microRNAs, the epithelial-mesenchymal transition (EMT) process; and on the cellular level are exemplified by effects on macrophages. We conclude that the thyroid hormone-αvβ interaction is mechanistically linked to cancer metastasis and that modified tetrac molecules have antimetastatic activity with feasible therapeutic potential.
原文英語
文章編號89
期刊Biomedicines
6
發行號3
DOIs
出版狀態已發佈 - 九月 1 2018

ASJC Scopus subject areas

  • 醫藥(雜項)
  • 生物化學、遺傳與分子生物學 (全部)

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