摘要
Background. The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR-RFLP was used to measure SDF-1-3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV. Conclusions. SDF-1-3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.
原文 | 英語 |
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頁(從 - 到) | 1282-1288 |
頁數 | 7 |
期刊 | Head and Neck |
卷 | 31 |
發行號 | 10 |
DOIs | |
出版狀態 | 已發佈 - 10月 2009 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 耳鼻咽喉科