Consumption of lycopene inhibits the growth and progression of colon cancer in a mouse xenograft model

Feng Yao Tang, Man Hui Pai, Xiang Dong Wang

研究成果: 雜誌貢獻文章同行評審

42 引文 斯高帕斯(Scopus)

摘要

A previous study indicated that lycopene could significantly inhibit the proliferation of human colon cancer cells in vitro. However, the in vivo anticancer effects of lycopene against colon cancer have not been demonstrated yet. Therefore, this study investigated whether consumption of lycopene could prevent the growth and progression of colorectal tumor in a mouse xenograft model. Bioluminescence imaging, histopathological, immunofluorescence (IFC), and immunohistochemical (IHC) staining results indicated that lycopene could effectively suppress the growth and progression of colon cancer in tumor-bearing mice. The results demonstrated that lycopene significantly suppressed the nuclear expression of PCNA and β-catenin proteins in tumor tissues. Consumption of lycopene could also augment the E-cadherin adherent molecule and nuclear levels of cell cycle inhibitor p21 CIP1/WAF1 protein. The chemopreventive effects of lycopene were associated with suppression of COX-2, PGE 2, and phosphorylated ERK1/2 proteins. Furthermore, the inhibitory effects of lycopene were inversely correlated with the plasma levels of matrix metalloproteinase 9 (MMP-9) in tumor-bearing mice. These results suggested that lycopene could act as a chemopreventive agent against the growth and progression of colorectal cancer in a mouse xenograft model.

原文英語
頁(從 - 到)9011-9021
頁數11
期刊Journal of Agricultural and Food Chemistry
59
發行號16
DOIs
出版狀態已發佈 - 八月 24 2011

ASJC Scopus subject areas

  • 農業與生物科學 (全部)
  • 化學 (全部)

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