Constituents of Polyalthia longifolia var. pendula

Zong-Huei Li, Mei Jhen Wang, Pi Yu Chen, Tung Ying Wu, Wu Che Wen, Fu Yu Tsai, Ching Kuo Lee

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

Three new clerodane-type diterpenes, 6R,16-dihydroxycleroda-3,13-dien-15- oic acid (1), 6α,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4α,18β-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3, 9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11- trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13- dien-15-oic acid (8) exhibited cytotoxicity.

原文英語
頁(從 - 到)1960-1963
頁數4
期刊Journal of Natural Products
72
發行號11
DOIs
出版狀態已發佈 - 11月 30 2009

ASJC Scopus subject areas

  • 補充和替代醫學
  • 分子醫學
  • 有機化學
  • 分析化學
  • 藥學科學
  • 藥理
  • 藥物發現

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