Congenital intractable diarrhea with possible defective crypt regeneration: report of a case.

R. L. Chen, M. H. Chang, C. L. Chen

研究成果: 雜誌貢獻文章同行評審

摘要

A male infant, born uneventfully from a consanguinous marriage, presented with intractable watery diarrhea from his third day of life, with subsequent malnutrition and failure to thrive. He received central parenteral nutrition beginning at three months of age after a poor response to a semielemental diet and peripheral parenteral nutrition. He was totally dependent on central parenteral nutrition thereafter. Although diarrhea disappeared with strict bowel rest, intolerance to minimal enteral feedings persisted throughout his 2 years 4 months of life. Investigations including stool examinations and repeated cultures, immune function studies, radiologic studies of the small bowel and screening for galactosemia and cystic fibrosis could not demonstrate a specific cause for the diarrhea. Repeated small intestinal biopsies at 1 month, 4 months and 1 year 5 months of age showed persistent villous atrophy with crypt hypoplasia and a low crypt mitotic index. Electron microscopic examination revealed normal-appearing microvilli. This child may have had a congenital enteropathy due to an inborn crypt regeneration defect causing lifelong intolerance to enteral feedings.

原文英語
頁(從 - 到)1194-1199
頁數6
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
90
發行號12
出版狀態已發佈 - 十二月 1991
對外發佈

ASJC Scopus subject areas

  • 醫藥 (全部)

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