Concomitant administration of live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) and measles, mumps, rubella (MMR) vaccine: Randomized study in toddlers in Taiwan

Li Min Huang, Tzou Yien Lin, Cheng Hsun Chiu, Nan Chang Chiu, Po Yen Chen, Shu Jen Yeh, Mark Boaz, Yanee Hutagalung, Alain Bouckenooghe, Emmanuel Feroldi

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

Background: Japanese encephalitis (JE) is the most important cause of viral encephalitis in Asia. Methods: In this randomized, open-label, multicenter trial in 550 children aged 12 to 18 months in Taiwan, children received one dose of JE-CV and one dose of MMR vaccine. Vaccines were either administered separately 6 weeks apart (Groups 'JE-CV' and 'MMR', named after which vaccine was given first), or concomitantly (Group 'Co-Ad'). JE neutralizing antibody titers were assessed using PRNT50. MMR antibody levels were determined by ELISA. Results: All groups had low seroprotection/seropositivity rates (<10%) before vaccination for all antigens. Forty two days after vaccination, on either Study Day 42 or 84, seroconversion rates for all antigens were high in all groups, irrespective of the order of vaccinations. Seroconversion for JE ranged from 96.9% in Group Co-Ad on D42 to 100% in Group MMR. Non-inferiority was demonstrated for all analyses as the lower bound of the 95% CI of the difference in seroconversion rates between groups was above the pre-defined limit of -10.0%. The immune responses remained high for all antigens and well above the level of protection 12 months after vaccination in all groups. There were no safety concerns. Conclusions: JE-CV is safe and induces a strong protective immune response which persists over 1 year when co-administered with MMR vaccine.
原文英語
頁(從 - 到)5363-5369
頁數7
期刊Vaccine
32
發行號41
DOIs
出版狀態已發佈 - 2014
對外發佈

ASJC Scopus subject areas

  • 免疫學與微生物學 (全部)
  • 傳染性疾病
  • 公共衛生、環境和職業健康
  • 獸醫 (全部)
  • 分子醫學
  • 醫藥 (全部)

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