Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Hsueh Yun Lee, Jang-Yang Chang, Ling-Yin Chang, Wen-Yang Lai, Mei-Jung Lai, Kuang-Hsing Shih, Ching-Chuan Kuo, Chi-Yen Chang, Jing Ping Liou

研究成果: 雜誌貢獻文章

18 引文 (Scopus)

摘要

In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.

原文英語
頁(從 - 到)3154-3157
頁數4
期刊Organic and Biomolecular Chemistry
9
發行號9
DOIs
出版狀態已發佈 - 五月 7 2011

指紋

Tubulin Modulators
Antimitotic Agents
disrupting
Stilbenes
stilbene
musculoskeletal system
Skeleton
inhibitors
halides
Blood Vessels
Copper
polymerization
copper
synthesis
fosbretabulin

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

引用此文

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents : Application of the copper-mediated Ullmann-type arylation. / Lee, Hsueh Yun; Chang, Jang-Yang; Chang, Ling-Yin; Lai, Wen-Yang; Lai, Mei-Jung; Shih, Kuang-Hsing; Kuo, Ching-Chuan; Chang, Chi-Yen; Liou, Jing Ping.

於: Organic and Biomolecular Chemistry, 卷 9, 編號 9, 07.05.2011, p. 3154-3157.

研究成果: 雜誌貢獻文章

Lee, Hsueh Yun ; Chang, Jang-Yang ; Chang, Ling-Yin ; Lai, Wen-Yang ; Lai, Mei-Jung ; Shih, Kuang-Hsing ; Kuo, Ching-Chuan ; Chang, Chi-Yen ; Liou, Jing Ping. / Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents : Application of the copper-mediated Ullmann-type arylation. 於: Organic and Biomolecular Chemistry. 2011 ; 卷 9, 編號 9. 頁 3154-3157.
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abstract = "In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.",
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AU - Chang, Jang-Yang

AU - Chang, Ling-Yin

AU - Lai, Wen-Yang

AU - Lai, Mei-Jung

AU - Shih, Kuang-Hsing

AU - Kuo, Ching-Chuan

AU - Chang, Chi-Yen

AU - Liou, Jing Ping

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