Compounds isolated from Euonymus spraguei Hayata induce ossification through multiple pathways

Zuha Imtiyaz, Yi Tzu Lin, Ut Hang Cheong, Alagie Jassey, Hui Kang Liu, Mei Hsien Lee

研究成果: 雜誌貢獻文章同行評審

摘要

The process of bone metabolism includes catabolism of old or mature bone and anabolism of new bone, carried out by osteoclasts and osteoblasts respectively. Any imbalance in this process results in loss of bone mass or osteoporosis. Drugs available to combat osteoporosis have certain adverse effects and are unable to improve bone formation, hence identifying new agents to fulfil these therapeutic gaps is required. To expand the scope of potential agents that enhance bone formation, we identified Euonymus spraguei Hayata as a plant material that possesses robust osteogenic potential using human osteoblast cells. We isolated three compounds, syringaresinol (1), syringin (2), and (−)-epicatechin (3), from E. spraguei. Results demonstrated that syringin (2), and (−)-epicatechin (3), increased alkaline phosphatase activity significantly up to 131.01% and 130.67%, respectively; they also elevated mineral deposition with respective values of up to 139.39% and 138.33%. In addition, 2 and 3 modulated autophagy and the bone morphogenetic protein (BMP)-2 signaling pathway. Our findings demonstrated that 2 and 3 induced osteogenesis by targeting multiple pathways and therefore can be considered as potent multi-targeted drugs for bone formation against osteoporosis.

原文英語
頁(從 - 到)2227-2237
頁數11
期刊Saudi Journal of Biological Sciences
27
發行號9
DOIs
出版狀態已發佈 - 九月 2020

ASJC Scopus subject areas

  • 農業與生物科學 (全部)

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