Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells

Feng Min Lin, Li Ru Chen, En Hau Lin, Ferng Chun Ke, Hsin Yi Chen, Meng Jen Tsai, Pei Wen Hsiao

研究成果: 雜誌貢獻文章同行評審

74 引文 斯高帕斯(Scopus)

摘要

Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anticancer therapeutic opportunity. Here, we report four anti-proliferative phytocompounds in Wedelia chinensis, an oriental herbal medicine, identified through their ability to modulate the androgen receptor (AR) activation of transcription from prostate-specific antigen promoter in PCa cells. The 50% inhibition concentration values of indole-3-carboxylaldehyde, wedelolactone, luteolin and apigenin, were 34.9, 0.2, 2.4 and 9.8 μM, respectively. A formula that combined the phytocompounds in the same proportions as in the herbal extract decreased the dosage of each compound required to achieve maximal AR inhibition. In correlation with the AR suppression effect, these active compounds specifically inhibited the growth of AR-dependent PCa cells and as a combination formula they also synergistically suppressed growth in AR-dependent PCa cells. Our study has identified synergistic effects of active compounds in W. chinensis and demonstrated their potential in PCa prevention and therapy. The paradigm of multiple activities and synergism is a useful framework to investigate the therapeutic effects of whole extracts from assorted medicinal plant species.
原文英語
頁(從 - 到)2521-2529
頁數9
期刊Carcinogenesis
28
發行號12
DOIs
出版狀態已發佈 - 十二月 2007
對外發佈

ASJC Scopus subject areas

  • 癌症研究

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