Composite nano-titanium oxide-chitosan artificial skin exhibits strong wound-healing effect - An approach with anti-inflammatory and bactericidal kinetics

Chiung Chi Peng, Ming Hua Yang, Wen Ta Chiu, Chun Hung Chiu, Chi Shen Yang, Yi Wen Chen, Kuan Chou Chen, Robert Y. Peng

研究成果: 雜誌貢獻文章同行評審

56 引文 斯高帕斯(Scopus)

摘要

A composite nano-TiO2-chitosan with collagen artificial skin (NTCAS) showed promising characteristics of moderate water absorptivity (110 wt.-%), fine thickness (0.34 mm), low density (0.33 mg ·mm-3), moderate biodegradability (-1 · h-1 on Day 0; 0.0006 mg·mL-1 · h-1 on Day 3 post covering). More importantly, it showed uniquely potent bactericidal (sterilization) property with relatively large values of pseudo first-order kinetic coefficients (0.1736-0.0360 min-1) for TiO2 contents ranging from 2.63 × 10-5 to 2.11 × 10-4 mg ·cm-2. In wounded subjects, NTCAS showed a steady level of TNF-α, while the IL-6 level reached a peak on Day 7, although significantly lower than in the control and Duoderm groups. In the animal model, NTCAS showed better and faster recovery than the other groups, which can be attributed to the unique bactericidal effect of nano-TiO2 and immune-enhancing effect of chitosan. NTCAS is a promising artificial skin substitute and is superior to any other market product currently in use. A figure is presented.
原文英語
頁(從 - 到)316-327
頁數12
期刊Macromolecular Bioscience
8
發行號4
DOIs
出版狀態已發佈 - 四月 9 2008
對外發佈

ASJC Scopus subject areas

  • 生物技術
  • 生物工程
  • 生物材料
  • 聚合物和塑料
  • 材料化學
  • 生物化學、遺傳與分子生物學 (全部)
  • 生物化學

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