Complications following D3 gastrectomy: Post hoc analysis of a randomized trial

Chew Wun Wu, I. Shou Chang, Su Shun Lo, Mao Chin Hsieh, Jen Hao Chen, Wing Yiu Lui, Jacqueline Whang-Peng

研究成果: 雜誌貢獻文章

32 引文 (Scopus)

摘要

Introduction: A single institutional surgical trial for gastric cancer had demonstrated increased morbidity but not mortality. This report analyzes risk factors affecting morbidity. Methods: Risk factors for morbidity in 221 patients treated with curative intent were evaluated in a prospective randomized trial comparing D1 and D3 surgery for curable gastric cancer. Results: The surgeon's experience after 25 nodal dissections had no influence on surgical or overall complications, nor did the patients' co-morbidity (e.g., respiratory system disease, cardiac disease, diabetes mellitus). Distal pancreatectomy negatively affected surgical morbidity [relative risk (RR) 6.21, 95% confidence interval (CI) 1.869-20.626] and overall morbidity (RR 5.50, 95% CI 1.671-18.082). All of the patients with a distal pancreatectomy underwent concomitant splenectomy. Multivariate analysis found splenectomy and nodal dissection to be the only two independent risk factors adversely affecting operative morbidity. The RR of splenectomy for surgical complications was 4.19 (95% CI 1.327-13.208), and for overall complications it was 3.88 (95% CI 1.259-11.973). The RR of nodal dissection for surgical complications was 2.51 (95% CI 1.336-4.730), and for overall complications it was 1.93 (95% CI 1.149-3.255). Conclusions: Splenectomy (with or without pancreatectomy) and nodal dissection are risk factors for operative morbidity but not mortality.
原文英語
頁(從 - 到)12-16
頁數5
期刊World Journal of Surgery
30
發行號1
DOIs
出版狀態已發佈 - 一月 1 2006
對外發佈Yes

指紋

Gastrectomy
Morbidity
Splenectomy
Confidence Intervals
Pancreatectomy
Dissection
Stomach Neoplasms
Mortality
Respiratory System
Heart Diseases
Diabetes Mellitus
Multivariate Analysis

ASJC Scopus subject areas

  • Surgery

引用此文

Complications following D3 gastrectomy : Post hoc analysis of a randomized trial. / Wu, Chew Wun; Chang, I. Shou; Lo, Su Shun; Hsieh, Mao Chin; Chen, Jen Hao; Lui, Wing Yiu; Whang-Peng, Jacqueline.

於: World Journal of Surgery, 卷 30, 編號 1, 01.01.2006, p. 12-16.

研究成果: 雜誌貢獻文章

Wu, Chew Wun ; Chang, I. Shou ; Lo, Su Shun ; Hsieh, Mao Chin ; Chen, Jen Hao ; Lui, Wing Yiu ; Whang-Peng, Jacqueline. / Complications following D3 gastrectomy : Post hoc analysis of a randomized trial. 於: World Journal of Surgery. 2006 ; 卷 30, 編號 1. 頁 12-16.
@article{20a1d43c0d6b4fcd8b4877eedad68a66,
title = "Complications following D3 gastrectomy: Post hoc analysis of a randomized trial",
abstract = "Introduction: A single institutional surgical trial for gastric cancer had demonstrated increased morbidity but not mortality. This report analyzes risk factors affecting morbidity. Methods: Risk factors for morbidity in 221 patients treated with curative intent were evaluated in a prospective randomized trial comparing D1 and D3 surgery for curable gastric cancer. Results: The surgeon's experience after 25 nodal dissections had no influence on surgical or overall complications, nor did the patients' co-morbidity (e.g., respiratory system disease, cardiac disease, diabetes mellitus). Distal pancreatectomy negatively affected surgical morbidity [relative risk (RR) 6.21, 95{\%} confidence interval (CI) 1.869-20.626] and overall morbidity (RR 5.50, 95{\%} CI 1.671-18.082). All of the patients with a distal pancreatectomy underwent concomitant splenectomy. Multivariate analysis found splenectomy and nodal dissection to be the only two independent risk factors adversely affecting operative morbidity. The RR of splenectomy for surgical complications was 4.19 (95{\%} CI 1.327-13.208), and for overall complications it was 3.88 (95{\%} CI 1.259-11.973). The RR of nodal dissection for surgical complications was 2.51 (95{\%} CI 1.336-4.730), and for overall complications it was 1.93 (95{\%} CI 1.149-3.255). Conclusions: Splenectomy (with or without pancreatectomy) and nodal dissection are risk factors for operative morbidity but not mortality.",
author = "Wu, {Chew Wun} and Chang, {I. Shou} and Lo, {Su Shun} and Hsieh, {Mao Chin} and Chen, {Jen Hao} and Lui, {Wing Yiu} and Jacqueline Whang-Peng",
year = "2006",
month = "1",
day = "1",
doi = "10.1007/s00268-005-7951-5",
language = "English",
volume = "30",
pages = "12--16",
journal = "World Journal of Surgery",
issn = "0364-2313",
publisher = "Springer New York LLC",
number = "1",

}

TY - JOUR

T1 - Complications following D3 gastrectomy

T2 - Post hoc analysis of a randomized trial

AU - Wu, Chew Wun

AU - Chang, I. Shou

AU - Lo, Su Shun

AU - Hsieh, Mao Chin

AU - Chen, Jen Hao

AU - Lui, Wing Yiu

AU - Whang-Peng, Jacqueline

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Introduction: A single institutional surgical trial for gastric cancer had demonstrated increased morbidity but not mortality. This report analyzes risk factors affecting morbidity. Methods: Risk factors for morbidity in 221 patients treated with curative intent were evaluated in a prospective randomized trial comparing D1 and D3 surgery for curable gastric cancer. Results: The surgeon's experience after 25 nodal dissections had no influence on surgical or overall complications, nor did the patients' co-morbidity (e.g., respiratory system disease, cardiac disease, diabetes mellitus). Distal pancreatectomy negatively affected surgical morbidity [relative risk (RR) 6.21, 95% confidence interval (CI) 1.869-20.626] and overall morbidity (RR 5.50, 95% CI 1.671-18.082). All of the patients with a distal pancreatectomy underwent concomitant splenectomy. Multivariate analysis found splenectomy and nodal dissection to be the only two independent risk factors adversely affecting operative morbidity. The RR of splenectomy for surgical complications was 4.19 (95% CI 1.327-13.208), and for overall complications it was 3.88 (95% CI 1.259-11.973). The RR of nodal dissection for surgical complications was 2.51 (95% CI 1.336-4.730), and for overall complications it was 1.93 (95% CI 1.149-3.255). Conclusions: Splenectomy (with or without pancreatectomy) and nodal dissection are risk factors for operative morbidity but not mortality.

AB - Introduction: A single institutional surgical trial for gastric cancer had demonstrated increased morbidity but not mortality. This report analyzes risk factors affecting morbidity. Methods: Risk factors for morbidity in 221 patients treated with curative intent were evaluated in a prospective randomized trial comparing D1 and D3 surgery for curable gastric cancer. Results: The surgeon's experience after 25 nodal dissections had no influence on surgical or overall complications, nor did the patients' co-morbidity (e.g., respiratory system disease, cardiac disease, diabetes mellitus). Distal pancreatectomy negatively affected surgical morbidity [relative risk (RR) 6.21, 95% confidence interval (CI) 1.869-20.626] and overall morbidity (RR 5.50, 95% CI 1.671-18.082). All of the patients with a distal pancreatectomy underwent concomitant splenectomy. Multivariate analysis found splenectomy and nodal dissection to be the only two independent risk factors adversely affecting operative morbidity. The RR of splenectomy for surgical complications was 4.19 (95% CI 1.327-13.208), and for overall complications it was 3.88 (95% CI 1.259-11.973). The RR of nodal dissection for surgical complications was 2.51 (95% CI 1.336-4.730), and for overall complications it was 1.93 (95% CI 1.149-3.255). Conclusions: Splenectomy (with or without pancreatectomy) and nodal dissection are risk factors for operative morbidity but not mortality.

UR - http://www.scopus.com/inward/record.url?scp=30544450986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30544450986&partnerID=8YFLogxK

U2 - 10.1007/s00268-005-7951-5

DO - 10.1007/s00268-005-7951-5

M3 - Article

C2 - 16369704

AN - SCOPUS:30544450986

VL - 30

SP - 12

EP - 16

JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

IS - 1

ER -