Complete remission of heavily treated ovarian clear cell carcinoma with ARID1A mutations after pembrolizumab and bevacizumab combination therapy: a case report

Yu Chien Lin, Kuo Chang Wen, Pi Lin Sung, Yu Ting Chou, Phui Ly Liew, Lin Yu Chen, Rui Lan Huang, Hung Cheng Lai, Lu Te Chang

研究成果: 雜誌貢獻文章同行評審

摘要

Background: Patients with ovarian clear cell carcinoma (OCCC) have a poor prognosis because they show low sensitivity to platinum-based chemotherapy. New treatments for refractory OCCC are urgently needed. Case presentation: We present a patient with refractory OCCC in whom conventional chemotherapy failed. Cachexia was induced by the disseminating recurrent tumors. Tumor tissue staining and genomic analysis revealed PD-L1 negativity, a low tumor burden, stable microsatellite instability, and two mutations in ARID1A. The patient was administered pembrolizumab combined with bevacizumab triweekly. Her serum CA-125 level decreased dramatically after the first cycle. A computerized tomography scan showed marked regression of the recurrent masses after 3 cycles, and the patient reached complete remission after 9 cycles. She showed good recovery from cachexia. We observed no marked side effects except for mild polyarthritis of the small joints. Conclusions: The therapeutic effect of checkpoint inhibitors combined with angiogenesis inhibitors is very promising in our patient with OCCC. Further clinical trials of tumors including ARID1A mutations are warranted.
原文英語
文章編號143
期刊Journal of Ovarian Research
13
發行號1
DOIs
出版狀態已發佈 - 十二月 2020

ASJC Scopus subject areas

  • 腫瘤科
  • 婦產科

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