Complete genomic sequences of the GP5 protein gene of bluetongue virus serotype 11 and 17

Yang Yi-Yuan, Joseph K K Li

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

The complete nucleotide sequences of full-length copies of genomic segment 6 or M3 of US bluetongue virus serotype 11 and 17 consisted of 1638 nucleotides. The plus-strand contained an open reading frame for a protein of 526 amino acids which was equivalent to about 59,000 Da, similar to the molecular weight of GP5 as determined by SDS-PAGE analysis. This long open reading frame was flanked by a 5' non-coding region of 29 nucleotides and a 3' non-coding region of 28 bases. When the predicted amino acid sequences of GP5 of BTV-11 and -17 were aligned and compared with those of BTV-2, -10, -13, -1AU and -1SA, four major highly conserved domains interrupted by several variable regions were detected. The potential significance of these discrete domains is discussed. Evolutionary and phylogenetic characteristics of these US BTV serotypes were consistent with our finding concerning BTV-1AU and -1SA.

原文英語
頁(從 - 到)163-171
頁數9
期刊Virus Research
23
發行號1-2
DOIs
出版狀態已發佈 - 1992
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Virology

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