Comparisons of risk factors and visual field changes between juvenile-onset and late-onset primary open-angle glaucoma

Yu Chieh Ko, Catherine Jui Ling Liu, Joe Ching Kuang Chou, Mei Ru Chen, Wen-Ming Hsu, Jorn Hon Liu

研究成果: 雜誌貢獻文章

13 引文 (Scopus)

摘要

Purpose: To identify the differences in risk factors and visual field (VF) changes between juvenile primary open-angle glaucoma (JOAG) and late-onset chronic open-angle glaucoma (COAG). Methods: The demographic and presenting clinical data of 27 JOAG and 30 COAG patients were retrospectively reviewed. Comparisons between the two groups were performed using Mann-Whitney U test, Wilcoxon signed-rank test, and Fisher's exact test. Results: A family history of glaucoma (37%) and a history of steroid usage (14.8%) were identified in JOAG patients only. The JOAG patients had a longer axial length (p < 0.001) and more often a myopic refractive state (p < 0.001) than the COAG patients. Patients with COAG showed a deeper (p = 0.016) and a more extensive (p = 0.008) defect in the superior than in the inferior hemifield, as well as a deeper (p = 0.016) and a more extensive (p = 0.001) defect in the superior than in the inferior arcuate area, while JOAG patients showed symmetric VF defects between the superior and inferior hemifields. Purely diffuse VF depression is more common in JOAG than in COAG patients (p = 0.03). Conclusions: JOAG patients demonstrated more axial myopic changes than patients with COAG as well as a pattern of superior-inferior symmetric VF defects. Axial myopia may play a critical role in the pathogenesis of JOAG.

原文英語
頁(從 - 到)27-32
頁數6
期刊Ophthalmologica
216
發行號1
DOIs
出版狀態已發佈 - 四月 6 2002
對外發佈Yes

指紋

Visual Fields
Open Angle Glaucoma
Nonparametric Statistics
Primary Open Angle Glaucoma
Myopia
Glaucoma
Steroids
Demography
Depression

ASJC Scopus subject areas

  • Ophthalmology

引用此文

Comparisons of risk factors and visual field changes between juvenile-onset and late-onset primary open-angle glaucoma. / Ko, Yu Chieh; Liu, Catherine Jui Ling; Chou, Joe Ching Kuang; Chen, Mei Ru; Hsu, Wen-Ming; Liu, Jorn Hon.

於: Ophthalmologica, 卷 216, 編號 1, 06.04.2002, p. 27-32.

研究成果: 雜誌貢獻文章

Ko, Yu Chieh ; Liu, Catherine Jui Ling ; Chou, Joe Ching Kuang ; Chen, Mei Ru ; Hsu, Wen-Ming ; Liu, Jorn Hon. / Comparisons of risk factors and visual field changes between juvenile-onset and late-onset primary open-angle glaucoma. 於: Ophthalmologica. 2002 ; 卷 216, 編號 1. 頁 27-32.
@article{effce07a4a814e7a894bb83cd1289027,
title = "Comparisons of risk factors and visual field changes between juvenile-onset and late-onset primary open-angle glaucoma",
abstract = "Purpose: To identify the differences in risk factors and visual field (VF) changes between juvenile primary open-angle glaucoma (JOAG) and late-onset chronic open-angle glaucoma (COAG). Methods: The demographic and presenting clinical data of 27 JOAG and 30 COAG patients were retrospectively reviewed. Comparisons between the two groups were performed using Mann-Whitney U test, Wilcoxon signed-rank test, and Fisher's exact test. Results: A family history of glaucoma (37{\%}) and a history of steroid usage (14.8{\%}) were identified in JOAG patients only. The JOAG patients had a longer axial length (p < 0.001) and more often a myopic refractive state (p < 0.001) than the COAG patients. Patients with COAG showed a deeper (p = 0.016) and a more extensive (p = 0.008) defect in the superior than in the inferior hemifield, as well as a deeper (p = 0.016) and a more extensive (p = 0.001) defect in the superior than in the inferior arcuate area, while JOAG patients showed symmetric VF defects between the superior and inferior hemifields. Purely diffuse VF depression is more common in JOAG than in COAG patients (p = 0.03). Conclusions: JOAG patients demonstrated more axial myopic changes than patients with COAG as well as a pattern of superior-inferior symmetric VF defects. Axial myopia may play a critical role in the pathogenesis of JOAG.",
keywords = "Age of onset, glaucoma, Myopia, Open-angle glaucoma, Risk factors, glaucoma, Visual field changes",
author = "Ko, {Yu Chieh} and Liu, {Catherine Jui Ling} and Chou, {Joe Ching Kuang} and Chen, {Mei Ru} and Wen-Ming Hsu and Liu, {Jorn Hon}",
year = "2002",
month = "4",
day = "6",
doi = "10.1159/000048293",
language = "English",
volume = "216",
pages = "27--32",
journal = "Ophthalmologica",
issn = "0030-3755",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Comparisons of risk factors and visual field changes between juvenile-onset and late-onset primary open-angle glaucoma

AU - Ko, Yu Chieh

AU - Liu, Catherine Jui Ling

AU - Chou, Joe Ching Kuang

AU - Chen, Mei Ru

AU - Hsu, Wen-Ming

AU - Liu, Jorn Hon

PY - 2002/4/6

Y1 - 2002/4/6

N2 - Purpose: To identify the differences in risk factors and visual field (VF) changes between juvenile primary open-angle glaucoma (JOAG) and late-onset chronic open-angle glaucoma (COAG). Methods: The demographic and presenting clinical data of 27 JOAG and 30 COAG patients were retrospectively reviewed. Comparisons between the two groups were performed using Mann-Whitney U test, Wilcoxon signed-rank test, and Fisher's exact test. Results: A family history of glaucoma (37%) and a history of steroid usage (14.8%) were identified in JOAG patients only. The JOAG patients had a longer axial length (p < 0.001) and more often a myopic refractive state (p < 0.001) than the COAG patients. Patients with COAG showed a deeper (p = 0.016) and a more extensive (p = 0.008) defect in the superior than in the inferior hemifield, as well as a deeper (p = 0.016) and a more extensive (p = 0.001) defect in the superior than in the inferior arcuate area, while JOAG patients showed symmetric VF defects between the superior and inferior hemifields. Purely diffuse VF depression is more common in JOAG than in COAG patients (p = 0.03). Conclusions: JOAG patients demonstrated more axial myopic changes than patients with COAG as well as a pattern of superior-inferior symmetric VF defects. Axial myopia may play a critical role in the pathogenesis of JOAG.

AB - Purpose: To identify the differences in risk factors and visual field (VF) changes between juvenile primary open-angle glaucoma (JOAG) and late-onset chronic open-angle glaucoma (COAG). Methods: The demographic and presenting clinical data of 27 JOAG and 30 COAG patients were retrospectively reviewed. Comparisons between the two groups were performed using Mann-Whitney U test, Wilcoxon signed-rank test, and Fisher's exact test. Results: A family history of glaucoma (37%) and a history of steroid usage (14.8%) were identified in JOAG patients only. The JOAG patients had a longer axial length (p < 0.001) and more often a myopic refractive state (p < 0.001) than the COAG patients. Patients with COAG showed a deeper (p = 0.016) and a more extensive (p = 0.008) defect in the superior than in the inferior hemifield, as well as a deeper (p = 0.016) and a more extensive (p = 0.001) defect in the superior than in the inferior arcuate area, while JOAG patients showed symmetric VF defects between the superior and inferior hemifields. Purely diffuse VF depression is more common in JOAG than in COAG patients (p = 0.03). Conclusions: JOAG patients demonstrated more axial myopic changes than patients with COAG as well as a pattern of superior-inferior symmetric VF defects. Axial myopia may play a critical role in the pathogenesis of JOAG.

KW - Age of onset, glaucoma

KW - Myopia

KW - Open-angle glaucoma

KW - Risk factors, glaucoma

KW - Visual field changes

UR - http://www.scopus.com/inward/record.url?scp=0036207444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036207444&partnerID=8YFLogxK

U2 - 10.1159/000048293

DO - 10.1159/000048293

M3 - Article

C2 - 11901285

AN - SCOPUS:0036207444

VL - 216

SP - 27

EP - 32

JO - Ophthalmologica

JF - Ophthalmologica

SN - 0030-3755

IS - 1

ER -