Comparison of the combined effects of atropine and neostigmine with atropine and edrophonium on the occurrence of postoperative nausea and vomiting.

C. H. Huang, M. J. Wang, L. Susetio, Y. G. Cherng, J. J. Shi, Y. A. Chen, W. H. Chiu

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

To investigate the effects of different types of anticholinesterase on the incidence of the postoperative nausea and vomiting, 100 ASA class I-II adult premenopausal female patients undergoing elective lower abdominal surgery were randomized into two groups. In both groups, anesthesia was induced with thiopental and fentanyl and 50% nitrous oxide and 0.5-1.5% of isoflurane were used for anesthetic maintenance with succinylcholine 1 approximately 1.5 mg/kg for intubation and atracurium 0.3 mg/kg/hr for maintenance of muscle relaxation. Patients received reversal agents for neuromuscular blockade after operation when the evoked train-of-four (TOF) count returned to four visual responses. A mixture of atropine 8 micrograms/kg and edrophonium 0.75 mg/kg was given to the first group of patients while atropine 15 micrograms/kg and neostigmine 40 micrograms/kg was given to another group of patients. All the patients were observed for the occurrence of nausea or vomiting for 2 hours after the operation in the recovery room. The incidence of nausea was not statistically significantly different in both groups (20% in neostigmine group and 26% in edrophonium group). The occurrence of vomiting was also similar in both groups (8% in neostigmine group and 6% in edrophonium group). We concluded that there were no difference in the incidence of postoperative nausea or vomiting with the use of either neostigmine or edrophonium with atropine for antagonizing neuromuscular blockade after the lower abdominal surgery.

原文英語
頁(從 - 到)113-116
頁數4
期刊Acta Anaesthesiologica Sinica
31
發行號2
出版狀態已發佈 - 六月 1993
對外發佈Yes

指紋

Edrophonium
Neostigmine
Postoperative Nausea and Vomiting
Atropine
Neuromuscular Blockade
Nausea
Vomiting
Incidence
Maintenance
Atracurium
Recovery Room
Succinylcholine
Muscle Relaxation
Thiopental
Isoflurane
Cholinesterase Inhibitors
Nitrous Oxide
Fentanyl
Intubation
Anesthetics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

引用此文

Comparison of the combined effects of atropine and neostigmine with atropine and edrophonium on the occurrence of postoperative nausea and vomiting. / Huang, C. H.; Wang, M. J.; Susetio, L.; Cherng, Y. G.; Shi, J. J.; Chen, Y. A.; Chiu, W. H.

於: Acta Anaesthesiologica Sinica, 卷 31, 編號 2, 06.1993, p. 113-116.

研究成果: 雜誌貢獻文章

Huang, C. H. ; Wang, M. J. ; Susetio, L. ; Cherng, Y. G. ; Shi, J. J. ; Chen, Y. A. ; Chiu, W. H. / Comparison of the combined effects of atropine and neostigmine with atropine and edrophonium on the occurrence of postoperative nausea and vomiting. 於: Acta Anaesthesiologica Sinica. 1993 ; 卷 31, 編號 2. 頁 113-116.
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abstract = "To investigate the effects of different types of anticholinesterase on the incidence of the postoperative nausea and vomiting, 100 ASA class I-II adult premenopausal female patients undergoing elective lower abdominal surgery were randomized into two groups. In both groups, anesthesia was induced with thiopental and fentanyl and 50{\%} nitrous oxide and 0.5-1.5{\%} of isoflurane were used for anesthetic maintenance with succinylcholine 1 approximately 1.5 mg/kg for intubation and atracurium 0.3 mg/kg/hr for maintenance of muscle relaxation. Patients received reversal agents for neuromuscular blockade after operation when the evoked train-of-four (TOF) count returned to four visual responses. A mixture of atropine 8 micrograms/kg and edrophonium 0.75 mg/kg was given to the first group of patients while atropine 15 micrograms/kg and neostigmine 40 micrograms/kg was given to another group of patients. All the patients were observed for the occurrence of nausea or vomiting for 2 hours after the operation in the recovery room. The incidence of nausea was not statistically significantly different in both groups (20{\%} in neostigmine group and 26{\%} in edrophonium group). The occurrence of vomiting was also similar in both groups (8{\%} in neostigmine group and 6{\%} in edrophonium group). We concluded that there were no difference in the incidence of postoperative nausea or vomiting with the use of either neostigmine or edrophonium with atropine for antagonizing neuromuscular blockade after the lower abdominal surgery.",
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