Comparison of intravenous nalbuphine infusion versus saline as an adjuvant for epidural morphine

Jhi Joung Wang, Shung Tai Ho, Oliver Yoa Pu Hu

研究成果: 雜誌貢獻文章

13 引文 (Scopus)

摘要

Background and Objectives. Radical (three-quadrant) hemorrhoidectomy is a major anorectal surgery that may necessitate aggressive pain management. This study was undertaken to determine whether intravenous nalbuphine infusion as an adjuvant to epidural morphine could offer not only a good quality of pain relief but also a lower incidence of side effects. Methods. Sixty patients requiring epidural anesthesia for radical hemorrhoidectomy were enrolled in a randomized, double-blind study. At the end of the surgery, all patients received epidural morphine 4 mg for relief of postoperative pain. Thereafter, 2 mg and 3 mg of morphine were administered via the epidural route at 8 p.m. and 8 a.m., respectively, for a 48-hour observation period. Patients in group 1 received an adjuvant intravenous infusion of nalbuphine 15 μg/kg/h, whereas patients in group 2 received intravenous saline only. A rescue analgesic of intramuscular meperidine 40 mg (every 4 hours) was available for each patient. Results. All patients had adequate postoperative pain relief. Cumulative (48-hour) analgesic requirements were similar. During the 48-hour observation period, one patient in group 1 and six in group 2 demonstrated a PaCO2 above 45 mm Hg. No patient had an SaO2 below 90%. The incidence of nausea and/or vomiting was 13% in group 1 and 62% in group 2. The incidence of pruritus was 7% in group 1 and 62% in group 2. Conclusions. The results suggest that intravenous nalbuphine infusion as an adjuvant for epidural morphine reduces the incidence of side effects without decreasing the quality of pain relief.
原文英語
頁(從 - 到)214-218
頁數5
期刊Regional Anesthesia
21
發行號3
出版狀態已發佈 - 五月 29 1996
對外發佈Yes

指紋

Nalbuphine
Intravenous Infusions
Morphine
Hemorrhoidectomy
Incidence
Postoperative Pain
Analgesics
Observation
Pain
Meperidine
Epidural Anesthesia
Pain Management
Pruritus
Double-Blind Method
Nausea
Vomiting

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

引用此文

Comparison of intravenous nalbuphine infusion versus saline as an adjuvant for epidural morphine. / Wang, Jhi Joung; Ho, Shung Tai; Hu, Oliver Yoa Pu.

於: Regional Anesthesia, 卷 21, 編號 3, 29.05.1996, p. 214-218.

研究成果: 雜誌貢獻文章

Wang, Jhi Joung ; Ho, Shung Tai ; Hu, Oliver Yoa Pu. / Comparison of intravenous nalbuphine infusion versus saline as an adjuvant for epidural morphine. 於: Regional Anesthesia. 1996 ; 卷 21, 編號 3. 頁 214-218.
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abstract = "Background and Objectives. Radical (three-quadrant) hemorrhoidectomy is a major anorectal surgery that may necessitate aggressive pain management. This study was undertaken to determine whether intravenous nalbuphine infusion as an adjuvant to epidural morphine could offer not only a good quality of pain relief but also a lower incidence of side effects. Methods. Sixty patients requiring epidural anesthesia for radical hemorrhoidectomy were enrolled in a randomized, double-blind study. At the end of the surgery, all patients received epidural morphine 4 mg for relief of postoperative pain. Thereafter, 2 mg and 3 mg of morphine were administered via the epidural route at 8 p.m. and 8 a.m., respectively, for a 48-hour observation period. Patients in group 1 received an adjuvant intravenous infusion of nalbuphine 15 μg/kg/h, whereas patients in group 2 received intravenous saline only. A rescue analgesic of intramuscular meperidine 40 mg (every 4 hours) was available for each patient. Results. All patients had adequate postoperative pain relief. Cumulative (48-hour) analgesic requirements were similar. During the 48-hour observation period, one patient in group 1 and six in group 2 demonstrated a PaCO2 above 45 mm Hg. No patient had an SaO2 below 90{\%}. The incidence of nausea and/or vomiting was 13{\%} in group 1 and 62{\%} in group 2. The incidence of pruritus was 7{\%} in group 1 and 62{\%} in group 2. Conclusions. The results suggest that intravenous nalbuphine infusion as an adjuvant for epidural morphine reduces the incidence of side effects without decreasing the quality of pain relief.",
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