Comparison of gram-negative and gram-positive hematogenous pyogenic spondylodiscitis: Clinical characteristics and outcomes of treatment

Ching Yu Lee, Meng Huang Wu, Chin Chang Cheng, Tsung-Jen Huang, Yu Tsung Huang, Chien Yin Lee, Jou Chen Huang, Yen Yao Li

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Background: To the best of our knowledge, no study has compared gram-negative bacillary hematogenous pyogenic spondylodiscitis (GNB-HPS) with gram-positive coccal hematogenous pyogenic spondylodiscitis (GPC-HPS) regarding their clinical characteristics and outcomes. Methods: From January 2003 to January 2013, 54 patients who underwent combined antibiotic and surgical therapy in the treatment of hematogenous pyogenic spondylodiscitis were included. Results: Compared with 37 GPC-HPS patients, the 17 GNB-HPS patients were more often found to be older individuals, a history of cancer, and a previous history of symptomatic urinary tract infection. They also had a less incidence of epidural abscess formation compared with GPC-HPS patients from findings on magnetic resonance imaging (MRI). Constitutional symptoms were the primary reasons for initial physician visits in GNB-HPS patients whereas pain in the affected spinal region was the most common manifestation in GPC-HPS patients at initial visit. The clinical outcomes of GNB-HPS patients under combined surgical and antibiotic treatment were not different from those of GPC-HPS patients. In multivariate analysis, independent predicting risk factors for GNB-HPS included a malignant history and constitutional symptoms and that for GPC-HPS was epidural abscess. Conclusions: The clinical manifestations and MRI presentations of GNB-HPS were distinguishable from those of GPC-HPS.
原文英語
文章編號735
期刊BMC Infectious Diseases
16
發行號1
DOIs
出版狀態已發佈 - 十二月 6 2016

指紋

Discitis
Epidural Abscess
Magnetic Resonance Imaging
Anti-Bacterial Agents
Urinary Tract Infections

ASJC Scopus subject areas

  • Infectious Diseases

引用此文

Comparison of gram-negative and gram-positive hematogenous pyogenic spondylodiscitis : Clinical characteristics and outcomes of treatment. / Lee, Ching Yu; Wu, Meng Huang; Cheng, Chin Chang; Huang, Tsung-Jen; Huang, Yu Tsung; Lee, Chien Yin; Huang, Jou Chen; Li, Yen Yao.

於: BMC Infectious Diseases, 卷 16, 編號 1, 735, 06.12.2016.

研究成果: 雜誌貢獻文章

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abstract = "Background: To the best of our knowledge, no study has compared gram-negative bacillary hematogenous pyogenic spondylodiscitis (GNB-HPS) with gram-positive coccal hematogenous pyogenic spondylodiscitis (GPC-HPS) regarding their clinical characteristics and outcomes. Methods: From January 2003 to January 2013, 54 patients who underwent combined antibiotic and surgical therapy in the treatment of hematogenous pyogenic spondylodiscitis were included. Results: Compared with 37 GPC-HPS patients, the 17 GNB-HPS patients were more often found to be older individuals, a history of cancer, and a previous history of symptomatic urinary tract infection. They also had a less incidence of epidural abscess formation compared with GPC-HPS patients from findings on magnetic resonance imaging (MRI). Constitutional symptoms were the primary reasons for initial physician visits in GNB-HPS patients whereas pain in the affected spinal region was the most common manifestation in GPC-HPS patients at initial visit. The clinical outcomes of GNB-HPS patients under combined surgical and antibiotic treatment were not different from those of GPC-HPS patients. In multivariate analysis, independent predicting risk factors for GNB-HPS included a malignant history and constitutional symptoms and that for GPC-HPS was epidural abscess. Conclusions: The clinical manifestations and MRI presentations of GNB-HPS were distinguishable from those of GPC-HPS.",
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author = "Lee, {Ching Yu} and Wu, {Meng Huang} and Cheng, {Chin Chang} and Tsung-Jen Huang and Huang, {Yu Tsung} and Lee, {Chien Yin} and Huang, {Jou Chen} and Li, {Yen Yao}",
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AU - Huang, Jou Chen

AU - Li, Yen Yao

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