Comparison of escitalopram and paroxetine in the treatment of major depressive disorder

Huang Li Lin, Ya Ting Hsu, Chia Yih Liu, Chia Hui Chen, Mei Chun Hsiao, Yu Li Liu, Winston W. Shen, Chin Fu Hsiao, Shen Ing Liu, Liang Huey Chang, Hwa Sheng Tang, Hsiang Ling Lai, Pei Sheng Lin, Keh Ming Lin, Hsiao Hui Tsou

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)


This is a single-blind, parallel, flexible-dose study to compare the efficacy and tolerability of escitalopram and paroxetine in the treatment of patients with major depressive disorder. We recruited 399 patients from the outpatient clinics of five hospitals in northern Taiwan. Patients were administered either escitalopram (10-30 mg) or paroxetine (20-40 mg) according to the judgment of clinicians. These patients were assessed using the Hamilton Rating Scale for Depression (HAM-D) and the Hamilton Rating Scale for Anxiety at weeks 0, 1, 2, 4, 6, and 8. A total of 302 patients fulfilled the evaluation criteria and were included in a statistical analysis. We found that escitalopram induced more significant symptom reduction and response rate in terms of the mean HAM-D scores at week 6 (P<0.05) and week 8 (P<0.05) than paroxetine, but that there were no significant differences between the two groups in the remission rate. Escitalopram induced significantly less frequency of adverse effects of weakness (P<0.01), nausea and vomiting (P<0.001), drowsiness (P<0.01) as well as somnolence (P<0.01) than paroxetine, although all these side effects were mild and tolerable. However for a more definitive result, future prospective trials with the inclusion of a placebo group and a double-blind design are needed. In patients who did not have severe depression (HAM-D score at baseline<21), but not in severely depressed patients, escitalopram was statistically superior to paroxetine, as shown by the mean change in the HAM-D score.
頁(從 - 到)339-345
期刊International Clinical Psychopharmacology
出版狀態已發佈 - 11月 2013

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 藥學(醫學)


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