Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China

Xinyi Niu, Kin Fai Ho, Hsiao Chi Chuang, Jian Sun, Yu Huang, Tafeng Hu, Hongmei Xu, Jing Duan, Ka Hei Lui, Junji Cao

研究成果: 雜誌貢獻文章

摘要

The chemical and bioreactivity properties of fine particulate matter (PM2.5) in indoor and outdoor environments in Xi'an were characterized, and the lung function of various participants was investigated. The concentrations of polycyclic aromatic hydrocarbons (PAHs), oxygenated polycyclic aromatic hydrocarbons, and nitrated polycyclic aromatic hydrocarbons were higher in outdoor environments than in indoor environments; in addition, urban areas had higher concentrations of these compounds than did suburban areas, with fossil fuel combustion likely being the primary source. Moreover, PM2.5-induced inflammation was higher in urban areas than in suburban areas. Indoor environments with coal combustion emissions showed relatively higher oxidative potential and inflammation. Moderate (phenanthrene) to strong (acenaphthylene and benzo(a)pyrene) correlations were observed between selected PAHs against interleukin 6 (IL-6), 8-hydroxy-desoxyguanosine (8-OHdG), and necrosis factor-α (TNF-α). Moreover, 9-fluorenone, 9,10-anthraquinone, and 5,12-naphthacenequinone exhibited higher oxidative stress and inflammation than did their parent PAHs. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively correlated with 8-OHdG, and FEV1/FVC was negatively correlated with TNF-α and IL-6. These findings—which integrates PM2.5 with lung function and bioreactivity analyses—suggest that coal burning, especially indoors, could elevate the cytotoxicity of PM2.5 to the occupants and that chronic exposure may lead to a decline in lung function.
原文英語
文章編號116929
期刊Atmospheric Environment
216
DOIs
出版狀態已發佈 - 十一月 1 2019

指紋

PAH
suburban area
urban area
phenanthrene
pyrene
fossil fuel
particulate matter
combustion
comparison
aromatic compound
cytotoxicity
coal
indoor environment

ASJC Scopus subject areas

  • Environmental Science(all)
  • Atmospheric Science

引用此文

Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China. / Niu, Xinyi; Ho, Kin Fai; Chuang, Hsiao Chi; Sun, Jian; Huang, Yu; Hu, Tafeng; Xu, Hongmei; Duan, Jing; Lui, Ka Hei; Cao, Junji.

於: Atmospheric Environment, 卷 216, 116929, 01.11.2019.

研究成果: 雜誌貢獻文章

Niu, Xinyi ; Ho, Kin Fai ; Chuang, Hsiao Chi ; Sun, Jian ; Huang, Yu ; Hu, Tafeng ; Xu, Hongmei ; Duan, Jing ; Lui, Ka Hei ; Cao, Junji. / Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China. 於: Atmospheric Environment. 2019 ; 卷 216.
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abstract = "The chemical and bioreactivity properties of fine particulate matter (PM2.5) in indoor and outdoor environments in Xi'an were characterized, and the lung function of various participants was investigated. The concentrations of polycyclic aromatic hydrocarbons (PAHs), oxygenated polycyclic aromatic hydrocarbons, and nitrated polycyclic aromatic hydrocarbons were higher in outdoor environments than in indoor environments; in addition, urban areas had higher concentrations of these compounds than did suburban areas, with fossil fuel combustion likely being the primary source. Moreover, PM2.5-induced inflammation was higher in urban areas than in suburban areas. Indoor environments with coal combustion emissions showed relatively higher oxidative potential and inflammation. Moderate (phenanthrene) to strong (acenaphthylene and benzo(a)pyrene) correlations were observed between selected PAHs against interleukin 6 (IL-6), 8-hydroxy-desoxyguanosine (8-OHdG), and necrosis factor-α (TNF-α). Moreover, 9-fluorenone, 9,10-anthraquinone, and 5,12-naphthacenequinone exhibited higher oxidative stress and inflammation than did their parent PAHs. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively correlated with 8-OHdG, and FEV1/FVC was negatively correlated with TNF-α and IL-6. These findings—which integrates PM2.5 with lung function and bioreactivity analyses—suggest that coal burning, especially indoors, could elevate the cytotoxicity of PM2.5 to the occupants and that chronic exposure may lead to a decline in lung function.",
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AU - Hu, Tafeng

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AB - The chemical and bioreactivity properties of fine particulate matter (PM2.5) in indoor and outdoor environments in Xi'an were characterized, and the lung function of various participants was investigated. The concentrations of polycyclic aromatic hydrocarbons (PAHs), oxygenated polycyclic aromatic hydrocarbons, and nitrated polycyclic aromatic hydrocarbons were higher in outdoor environments than in indoor environments; in addition, urban areas had higher concentrations of these compounds than did suburban areas, with fossil fuel combustion likely being the primary source. Moreover, PM2.5-induced inflammation was higher in urban areas than in suburban areas. Indoor environments with coal combustion emissions showed relatively higher oxidative potential and inflammation. Moderate (phenanthrene) to strong (acenaphthylene and benzo(a)pyrene) correlations were observed between selected PAHs against interleukin 6 (IL-6), 8-hydroxy-desoxyguanosine (8-OHdG), and necrosis factor-α (TNF-α). Moreover, 9-fluorenone, 9,10-anthraquinone, and 5,12-naphthacenequinone exhibited higher oxidative stress and inflammation than did their parent PAHs. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively correlated with 8-OHdG, and FEV1/FVC was negatively correlated with TNF-α and IL-6. These findings—which integrates PM2.5 with lung function and bioreactivity analyses—suggest that coal burning, especially indoors, could elevate the cytotoxicity of PM2.5 to the occupants and that chronic exposure may lead to a decline in lung function.

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