Comparison of continuous epidural infusion of fentanyl and fentanyl-bupivacaine for post cholecystectomy pain control.

F. Y. Huang, S. Z. Fan, M. S. Wang, Ta-Liang Chen, W. Z. Sun, S. Y. Lin

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Epidural narcotics has been shown to produce profound and long-lasting analgesia. It has been suggested that lipid-soluble narcotics such as fentanyl, because of their short transit time in the CSF, are less likely to be associated with delayed respiratory depression and side effects. We tried to combine low concentrations of fentanyl with bupivacaine to minimize side effects and to see if synergistic effect existed. Forty ASA physical status I or II patients who present for cholecystectomy were included in the trial. Before surgery a thoracic epidural catheter was inserted and pain control began when patients became fully awake and complained of pain in the recovery room after surgery. Patients were randomized in a double-blind fashion to one of four groups. Patients in group I were given epidural infusions of fentanyl 0.001%; patients in group 2 received fentanyl 0.001% mixed with bupivacaine 0.1%; patients in group 3 received fentanyl 0.0005%; patients in group 4 received fentanyl 0.0005% mixed with bupivacaine 0.1%. A continuous epidural infusion of these drugs began at a rate of 10 mL/h after a 5-mL bolus of the solution. Pain relief was assessed with visual analogue pain scale. Respiratory rates, vital signs, and mental status were assessed hourly. Except the group 3, the degree of analgesia achieved was similarly satisfactory in all other groups. There was no respiratory depression developed in either group. Motor block was minimal or absent in all groups. The incidence of nausea and pruritus was significant less in group 3 and group 4. In conclusion, the continuous infusion of dilute bupivacaine with fentanyl provides synergistic analgesia with minimal side effects.

原文英語
頁(從 - 到)9-13
頁數5
期刊Acta Anaesthesiologica Sinica
28
發行號1
出版狀態已發佈 - 三月 1990
對外發佈Yes

指紋

Bupivacaine
Cholecystectomy
Fentanyl
Pain
Analgesia
Narcotics
Respiratory Insufficiency
Recovery Room
Vital Signs
Pain Measurement
Pruritus
Respiratory Rate
Nausea
Thoracic Surgery
Catheters
Lipids
Incidence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

引用此文

Comparison of continuous epidural infusion of fentanyl and fentanyl-bupivacaine for post cholecystectomy pain control. / Huang, F. Y.; Fan, S. Z.; Wang, M. S.; Chen, Ta-Liang; Sun, W. Z.; Lin, S. Y.

於: Acta Anaesthesiologica Sinica, 卷 28, 編號 1, 03.1990, p. 9-13.

研究成果: 雜誌貢獻文章

Huang, F. Y. ; Fan, S. Z. ; Wang, M. S. ; Chen, Ta-Liang ; Sun, W. Z. ; Lin, S. Y. / Comparison of continuous epidural infusion of fentanyl and fentanyl-bupivacaine for post cholecystectomy pain control. 於: Acta Anaesthesiologica Sinica. 1990 ; 卷 28, 編號 1. 頁 9-13.
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abstract = "Epidural narcotics has been shown to produce profound and long-lasting analgesia. It has been suggested that lipid-soluble narcotics such as fentanyl, because of their short transit time in the CSF, are less likely to be associated with delayed respiratory depression and side effects. We tried to combine low concentrations of fentanyl with bupivacaine to minimize side effects and to see if synergistic effect existed. Forty ASA physical status I or II patients who present for cholecystectomy were included in the trial. Before surgery a thoracic epidural catheter was inserted and pain control began when patients became fully awake and complained of pain in the recovery room after surgery. Patients were randomized in a double-blind fashion to one of four groups. Patients in group I were given epidural infusions of fentanyl 0.001{\%}; patients in group 2 received fentanyl 0.001{\%} mixed with bupivacaine 0.1{\%}; patients in group 3 received fentanyl 0.0005{\%}; patients in group 4 received fentanyl 0.0005{\%} mixed with bupivacaine 0.1{\%}. A continuous epidural infusion of these drugs began at a rate of 10 mL/h after a 5-mL bolus of the solution. Pain relief was assessed with visual analogue pain scale. Respiratory rates, vital signs, and mental status were assessed hourly. Except the group 3, the degree of analgesia achieved was similarly satisfactory in all other groups. There was no respiratory depression developed in either group. Motor block was minimal or absent in all groups. The incidence of nausea and pruritus was significant less in group 3 and group 4. In conclusion, the continuous infusion of dilute bupivacaine with fentanyl provides synergistic analgesia with minimal side effects.",
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