Comparing the Relationship of Taxol-Based Chemotherapy Response with P-glycoprotein and Lung Resistance-Related Protein Expression in Non-Small Cell Lung Cancer

J. F. Chiou, J. A. Liang, W. H. Hsu, J. J. Wang, S. T. Ho, A. Kao

研究成果: 雜誌貢獻文章同行評審

41 引文 斯高帕斯(Scopus)

摘要

Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients with advanced NSCLC before Taxol-based chemotherapy. The chemotherapy response was evaluated by clinical and radiological methods in the third month after completion of treatment. No significant differences of prognostic factors (age, sex, body weight loss, performance status, tumor size, tumor stage, and tumor cell type) were found between the 20 patients with good and the 20 patients with poor responses. The incidence difference of positive Pgp expressions between good and poor responses wat.s significant, however, the difference of LRP expression was no We concluded that Taxol-based chemotherapy response of patients with NSCLC was related to Pgp but not LPR expression.

原文英語
頁(從 - 到)267-273
頁數7
期刊Lung
181
發行號5
DOIs
出版狀態已發佈 - 2003

ASJC Scopus subject areas

  • 肺和呼吸系統醫學
  • 生理學

指紋

深入研究「Comparing the Relationship of Taxol-Based Chemotherapy Response with P-glycoprotein and Lung Resistance-Related Protein Expression in Non-Small Cell Lung Cancer」主題。共同形成了獨特的指紋。

引用此