Common carotid artery end-diastolic velocity is independently associated with future cardiovascular events

Shao Yuan Chuang, Chyi-Huey Bai, Hao Ming Cheng, Jiunn Rong Chen, Wen Ting Yeh, Pai Feng Hsu, Wen Ling Liu, W. H. Pan

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

Background Carotid ultrasound is widely used to measure haemodynamic parameters, such as intima-media thickness and blood flow velocities (i.e. peak-systolic velocity [PSV], end-diastolic velocity [EDV], and resistive index [RI]). However, the association between blood flow velocities and cardiovascular events remains unclear. Design and methods Baseline data, including quantitative ultrasonography, were obtained from 3146 adults as part of the Cardiovascular Diseases Risk Factor Two-Township Study. Occurrence of ischaemic heart disease (IHD) and stroke was determined from insurance claims and death certificates. The hazard ratio (HR) of CVD (IHD and stroke combined) was calculated for EDV and PSV of the common carotid artery using Cox models. Net reclassification index and integrated discrimination index were used to evaluate the capacity of EDV to predict IHD, stroke, and CVD. Results Median follow-up was 12.8 years. There were 220 cases of IHD and 247 cases of stroke. The HR (95% CI) for CVD from univariate analysis was 4.54 (3.51-5.85) for EDV <15 cm/s relative to EDV ≥ 20 cm/s (p < 0.0001), and 3.23 (2.51-4.15) for PSV < 65 cm/s relative to PSV ≥ 80 cm/s (p < 0.0001). The HR (95% CI) for CVD from multivariate analysis was 1.66 (1.22-2.26) for EDV < 15 cm/s relative to EDV ≥ 20 cm/s, and 1.39 (1.03-1.89) for PSV < 65 cm/s relative to PSV ≥ 80 cm/s. EDV slightly but significantly improved prediction of CVD (integrated discrimination index 0.56%, p = 0.016). Conclusions Low common carotid EDV and PSV were independently associated with future CVD, and EDV improved the prediction of future CVD. More prospective studies are required in different ethnic groups to understand the significance and implication of these findings.
原文英語
頁(從 - 到)116-124
頁數9
期刊European Journal of Preventive Cardiology
23
發行號2
DOIs
出版狀態已發佈 - 一月 1 2016

指紋

Common Carotid Artery
Myocardial Ischemia
Stroke
Blood Flow Velocity
Death Certificates
Insurance
Proportional Hazards Models
Ultrasonography
Cardiovascular Diseases
Hemodynamics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Epidemiology

引用此文

Common carotid artery end-diastolic velocity is independently associated with future cardiovascular events. / Chuang, Shao Yuan; Bai, Chyi-Huey; Cheng, Hao Ming; Chen, Jiunn Rong; Yeh, Wen Ting; Hsu, Pai Feng; Liu, Wen Ling; Pan, W. H.

於: European Journal of Preventive Cardiology, 卷 23, 編號 2, 01.01.2016, p. 116-124.

研究成果: 雜誌貢獻文章

Chuang, Shao Yuan ; Bai, Chyi-Huey ; Cheng, Hao Ming ; Chen, Jiunn Rong ; Yeh, Wen Ting ; Hsu, Pai Feng ; Liu, Wen Ling ; Pan, W. H. / Common carotid artery end-diastolic velocity is independently associated with future cardiovascular events. 於: European Journal of Preventive Cardiology. 2016 ; 卷 23, 編號 2. 頁 116-124.
@article{56c5758bbe62419083aabd9ba523fb0a,
title = "Common carotid artery end-diastolic velocity is independently associated with future cardiovascular events",
abstract = "Background Carotid ultrasound is widely used to measure haemodynamic parameters, such as intima-media thickness and blood flow velocities (i.e. peak-systolic velocity [PSV], end-diastolic velocity [EDV], and resistive index [RI]). However, the association between blood flow velocities and cardiovascular events remains unclear. Design and methods Baseline data, including quantitative ultrasonography, were obtained from 3146 adults as part of the Cardiovascular Diseases Risk Factor Two-Township Study. Occurrence of ischaemic heart disease (IHD) and stroke was determined from insurance claims and death certificates. The hazard ratio (HR) of CVD (IHD and stroke combined) was calculated for EDV and PSV of the common carotid artery using Cox models. Net reclassification index and integrated discrimination index were used to evaluate the capacity of EDV to predict IHD, stroke, and CVD. Results Median follow-up was 12.8 years. There were 220 cases of IHD and 247 cases of stroke. The HR (95{\%} CI) for CVD from univariate analysis was 4.54 (3.51-5.85) for EDV",
keywords = "End-diastolic velocity, ischaemic heart disease, risk assessment and risk reclassification, stroke",
author = "Chuang, {Shao Yuan} and Chyi-Huey Bai and Cheng, {Hao Ming} and Chen, {Jiunn Rong} and Yeh, {Wen Ting} and Hsu, {Pai Feng} and Liu, {Wen Ling} and Pan, {W. H.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1177/2047487315571888",
language = "English",
volume = "23",
pages = "116--124",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Common carotid artery end-diastolic velocity is independently associated with future cardiovascular events

AU - Chuang, Shao Yuan

AU - Bai, Chyi-Huey

AU - Cheng, Hao Ming

AU - Chen, Jiunn Rong

AU - Yeh, Wen Ting

AU - Hsu, Pai Feng

AU - Liu, Wen Ling

AU - Pan, W. H.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background Carotid ultrasound is widely used to measure haemodynamic parameters, such as intima-media thickness and blood flow velocities (i.e. peak-systolic velocity [PSV], end-diastolic velocity [EDV], and resistive index [RI]). However, the association between blood flow velocities and cardiovascular events remains unclear. Design and methods Baseline data, including quantitative ultrasonography, were obtained from 3146 adults as part of the Cardiovascular Diseases Risk Factor Two-Township Study. Occurrence of ischaemic heart disease (IHD) and stroke was determined from insurance claims and death certificates. The hazard ratio (HR) of CVD (IHD and stroke combined) was calculated for EDV and PSV of the common carotid artery using Cox models. Net reclassification index and integrated discrimination index were used to evaluate the capacity of EDV to predict IHD, stroke, and CVD. Results Median follow-up was 12.8 years. There were 220 cases of IHD and 247 cases of stroke. The HR (95% CI) for CVD from univariate analysis was 4.54 (3.51-5.85) for EDV

AB - Background Carotid ultrasound is widely used to measure haemodynamic parameters, such as intima-media thickness and blood flow velocities (i.e. peak-systolic velocity [PSV], end-diastolic velocity [EDV], and resistive index [RI]). However, the association between blood flow velocities and cardiovascular events remains unclear. Design and methods Baseline data, including quantitative ultrasonography, were obtained from 3146 adults as part of the Cardiovascular Diseases Risk Factor Two-Township Study. Occurrence of ischaemic heart disease (IHD) and stroke was determined from insurance claims and death certificates. The hazard ratio (HR) of CVD (IHD and stroke combined) was calculated for EDV and PSV of the common carotid artery using Cox models. Net reclassification index and integrated discrimination index were used to evaluate the capacity of EDV to predict IHD, stroke, and CVD. Results Median follow-up was 12.8 years. There were 220 cases of IHD and 247 cases of stroke. The HR (95% CI) for CVD from univariate analysis was 4.54 (3.51-5.85) for EDV

KW - End-diastolic velocity

KW - ischaemic heart disease

KW - risk assessment and risk reclassification

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=84953206220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953206220&partnerID=8YFLogxK

U2 - 10.1177/2047487315571888

DO - 10.1177/2047487315571888

M3 - Article

VL - 23

SP - 116

EP - 124

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 2

ER -