Combining the observation of cell morphology with the evaluation of key inflammatory mediators to assess the anti-inflammatory effects of geranyl flavonoid derivatives in breadfruit

Jer An Lin, Chi Hao Wu, Song Chwan Fang, Gow Chin Yen

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Ligation of the receptor for advanced glycation end products (RAGE) is critical for monocyte activation involved in diabetic inflammation. In this study, the effects of the geranyl flavonoid derivatives (6-geranyl-7,4′- dihydroxyflavanone, AC-1; 4,2′,4′-trihydroxy-3′-[6-hydroxy-3, 7-dimethyl-2(E),7-octadienyl]chalcone, AC-2; 3,4,2′,4′-tetrahydroxy- 3′-geranyldihydrochalcone, AC-3; 4,2′,4′-trihydroxy-5′- geranyldihydrochalcone, AC-4) isolated from the fruit of Artocarpus communis (breadfruit) on the human THP-1 monocyte (THP-1) activation stimulated by S100B, a ligand of RAGE, were evaluated. The morphology of S100B-induced THP-1, which may be essential for the elucidation of the functional role of S100B in monocyte activation was investigated. We also directly demonstrated that S100B-induced THP-1 exhibited the morphological characteristics of inflammation, which were inhibited by the addition of AC-2, AC-3 or AC-4. Moreover, AC-2, AC-3 or AC-4 inhibited S100B-induced ROS generation, mRNA expression of inflammatory mediators (COX-2, TNF-α, IL-6 and RAGE) and IL-6 secretion. Thus, geranyl flavonoid derivatives of breadfruit may have potent implications to prevent diabetic inflammation.

原文英語
頁(從 - 到)2118-2125
頁數8
期刊Food Chemistry
132
發行號4
DOIs
出版狀態已發佈 - 六月 15 2012
對外發佈

ASJC Scopus subject areas

  • 分析化學
  • 食品科學

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