Combining portable solar-powered centrifuge to nanoplasmonic sensing chip with smartphone reader for rheumatoid arthritis detection

Prakhar Dutta, Ting Yu Su, An Ying Fu, Mei Chi Chang, Yu Jie Guo, I. Jung Tsai, Pei Kuen Wei, Yu Sheng Chang, Ching Yu Lin, Yu Jui Fan

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

In this study, we developed a portable solar-powered centrifuge designed to provide access to centrifugation in remote areas of the world with scarce resources. The autoantibodies in patients’ blood, after centrifuging, were evaluated by nanoplamonic chip integrated with smartphone reader for rheumatoid arthritis detection. The centrifuge is capable of providing a yield of around 45% and plasma purity of around 98% with whole blood in approximately 75 s, after which further testing can be carried out. The device is modular and can be used with a variety of parts for different purposes. A novel peptide developed in our previous study, after thiol group modifying, was conjugated to nanoplasmonic sensing chip. The change of nanoplamonic emitted from sensing chip before/after autoantibody capturing can be evaluated by analyzing red color intensity of the images of the nanoplasmonic captured by smartphone. We demonstrated that the device is capable of working under different conditions and requires minimal energy, which can be generated by a simple solar panel to increase accessibility in areas without electricity. Further, the nanoplasmonic sensing chip, analyzing by image method and images captured by smartphone microscope, showed potential to implement in powerless area as well.
原文英語
文章編號133864
頁(從 - 到)133864
期刊Chemical Engineering Journal
434
DOIs
出版狀態已發佈 - 4月 2022

ASJC Scopus subject areas

  • 化學 (全部)
  • 環境化學
  • 化學工程 (全部)
  • 工業與製造工程

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