Background/Purpose: Insulin resistance may play an important role in the pathogenesis of Type 2 diabetes in subjects infected with chronic hepatitis C virus (HCV). A combination therapy of interferon-α (IFN-α) plus ribavirin has been the mainstay of treatment for chronic HCV infection. Changes in insulin resistance and adiponectin levels after such a combination therapy, especially in Asian populations, are rarely reported. Hence, we performed this study to assess these changes before, during, and after the combination therapy. Methods: The degree of homeostasis model assessment of insulin resistance and adiponectin levels were evaluated in nondiabetic subjects affiliated with chronic HCV before treatment and at 3 and 6 months, respectively, after the cessation of the combined therapy of IFN-α plus ribavirin. Results: The parameters obtained before, during, and after cessation of the therapy showed that the degree of homeostasis model assessment of insulin resistance significantly changed over time with age-, sex-, and body mass index-adjusted conditions. In contrast, adiponectin levels were totally unaffected. Conclusion: The extent of insulin resistance can be improved by the IFN-α plus ribavirin combination therapy. Despite a significant improvement in insulin resistance, the adiponectin levels remained unaffected.
|頁（從 - 到）||46-49|
|期刊||Journal of Experimental and Clinical Medicine(Taiwan)|
|出版狀態||已發佈 - 2月 2011|
ASJC Scopus subject areas
- 醫藥 (全部)