Combined splenectomy does not improve survival in radical total gastrectomy for advanced gastric cardia cancer

Wen Liang Fang, Kuo Hung Huang, Chew Wun Wu, Jen Hao Chen, Su Shun Lo, Mao Chih Hsieh, King Han Shen, Anna Fen Yau Li

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Background/Aims: Splenectomy is the most common combined organ resection in the surgical management for gastric cardia cancer. The role of combined splenectomy is still controversial. Methodology: From January 1998 to December 2006, a total of 174 patients received radical total gastrectomy for advanced adenocarcinoma of cardia. Patients with previous gastric surgery or tumor invasion of pancreas or spleen were excluded. Among them, 115 patients were enrolled in this study. Patients were divided into group 1 (splenectomy, n=47) and group 2 (spleen preservation, n=68). Their clinicopathological characteristics were compared. Results: Multivariate analysis showed that only tumor size and lymphovascular invasion were two independent indicators of survival. The surgically-related morbidity and mortality rates were similar between the two groups. Among the 3 patients with splenic hilar lymph nodes metastasis, all of them had large tumor size (≥4cm), advanced stage (stage III and IV) and tumor center located at the posterior wall of stomach. The 5-year overall survival for advanced cancer was similar (57.1% vs. 60.2%, p=0.681). Conclusions: Splenectomy does not improve overall survival in the management of advanced gastric cardia cancer. Splenectomy has limited clinical benefits except for large advanced tumors located at the posterior wall of stomach.
原文英語
頁(從 - 到)1150-1154
頁數5
期刊Hepato-Gastroenterology
59
發行號116
DOIs
出版狀態已發佈 - 六月 2012

ASJC Scopus subject areas

  • 消化內科
  • 肝病

指紋

深入研究「Combined splenectomy does not improve survival in radical total gastrectomy for advanced gastric cardia cancer」主題。共同形成了獨特的指紋。

引用此