Combined Framingham risk score and coronary artery calcium score predict subclinical coronary plaque assessed by coronary computed tomography angiogram in asymptomatic Taiwanese population

Jong Shiuan Yeh, Yung Ta Kao, Feng-Yen Lin, Chun-Ming Shih, Nai-Wen Tsao, Chao Shun Chan, Ming-Hsiung Hsieh, Kou-Gi Shyu, Jaw Wen Chen, Nen-Chung Chang, Chun-Yao Huang

研究成果: 雜誌貢獻文章

摘要

Background:We sought to determine the predictive value of the combined traditional Framingham risk score (FRS) and coronary artery calcium score (CACS) for subclinical coronary plaque detected by computed tomography coronary angiogram (CTCA) in asymptomatic subjects. Method: We evaluated 167 asymptomatic Taiwanese subjects (mean age, 57 - 11.2 years), who underwent CTCA as part of a health evaluation.We examined the associations between FRS, CACS, serum biomarkers, and coronary plaque assessed by CTCA. Results: Out of 167 subjects in the study, 95 had coronary artery atheroma. Of those possible predictors for coronary atherosclerosis, both FRS and CACS were independent predictors for the presence of coronary plaque [relative risk (RR): 1.29, 95% confidence interval (CI): 1.07-1.54, p = 0.006 and RR: 1.42, 95% CI: 1.16-1.75, p = 0.001, respectively]. Receiver operating characteristics curve analysis revealed that CACS and FRS were indicators of the presence of coronary plaque. The area under the curve for FRS and CACS was 0.729 and 0.889, respectively (p <0.001). Furthermore, the area under the curve for combination of FRS and CACS was 0.936 (95% CI: 0.887-0.969, p <0.001), and this combination provided a better diagnostic advantage than either FRS or CACS alone (p <0.001 and p = 0.012 by C-statistic, respectively). Conclusions: In asymptomatic Taiwanese subjects with low to intermediate cardiovascular risk, both FRS and CACS were independently related to subclinical atherosclerosis. A combined FRS and CACS evaluation improved the efficacy of prediction for atherosclerotic plaque burden.
原文英語
頁(從 - 到)429-435
頁數7
期刊Acta Cardiologica Sinica
29
發行號5
出版狀態已發佈 - 九月 2013

指紋

Coronary Vessels
Angiography
Tomography
Calcium
Population
Atherosclerotic Plaques
Confidence Intervals
Area Under Curve
ROC Curve
Coronary Artery Disease
Atherosclerosis
Biomarkers
Health
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

@article{a2a97d084d2544368cb97fa3859ad298,
title = "Combined Framingham risk score and coronary artery calcium score predict subclinical coronary plaque assessed by coronary computed tomography angiogram in asymptomatic Taiwanese population",
abstract = "Background:We sought to determine the predictive value of the combined traditional Framingham risk score (FRS) and coronary artery calcium score (CACS) for subclinical coronary plaque detected by computed tomography coronary angiogram (CTCA) in asymptomatic subjects. Method: We evaluated 167 asymptomatic Taiwanese subjects (mean age, 57 - 11.2 years), who underwent CTCA as part of a health evaluation.We examined the associations between FRS, CACS, serum biomarkers, and coronary plaque assessed by CTCA. Results: Out of 167 subjects in the study, 95 had coronary artery atheroma. Of those possible predictors for coronary atherosclerosis, both FRS and CACS were independent predictors for the presence of coronary plaque [relative risk (RR): 1.29, 95{\%} confidence interval (CI): 1.07-1.54, p = 0.006 and RR: 1.42, 95{\%} CI: 1.16-1.75, p = 0.001, respectively]. Receiver operating characteristics curve analysis revealed that CACS and FRS were indicators of the presence of coronary plaque. The area under the curve for FRS and CACS was 0.729 and 0.889, respectively (p <0.001). Furthermore, the area under the curve for combination of FRS and CACS was 0.936 (95{\%} CI: 0.887-0.969, p <0.001), and this combination provided a better diagnostic advantage than either FRS or CACS alone (p <0.001 and p = 0.012 by C-statistic, respectively). Conclusions: In asymptomatic Taiwanese subjects with low to intermediate cardiovascular risk, both FRS and CACS were independently related to subclinical atherosclerosis. A combined FRS and CACS evaluation improved the efficacy of prediction for atherosclerotic plaque burden.",
keywords = "Atherosclerosis, Computed coronary tomography angiogram, Coronary artery calcium score, Framingham risk score, Subclinical coronary plaque",
author = "Yeh, {Jong Shiuan} and Kao, {Yung Ta} and Feng-Yen Lin and Chun-Ming Shih and Nai-Wen Tsao and Chan, {Chao Shun} and Ming-Hsiung Hsieh and Kou-Gi Shyu and Chen, {Jaw Wen} and Nen-Chung Chang and Chun-Yao Huang",
year = "2013",
month = "9",
language = "English",
volume = "29",
pages = "429--435",
journal = "Acta Cardiologica Sinica",
issn = "1011-6842",
publisher = "Republic of China Society of Cardiology",
number = "5",

}

TY - JOUR

T1 - Combined Framingham risk score and coronary artery calcium score predict subclinical coronary plaque assessed by coronary computed tomography angiogram in asymptomatic Taiwanese population

AU - Yeh, Jong Shiuan

AU - Kao, Yung Ta

AU - Lin, Feng-Yen

AU - Shih, Chun-Ming

AU - Tsao, Nai-Wen

AU - Chan, Chao Shun

AU - Hsieh, Ming-Hsiung

AU - Shyu, Kou-Gi

AU - Chen, Jaw Wen

AU - Chang, Nen-Chung

AU - Huang, Chun-Yao

PY - 2013/9

Y1 - 2013/9

N2 - Background:We sought to determine the predictive value of the combined traditional Framingham risk score (FRS) and coronary artery calcium score (CACS) for subclinical coronary plaque detected by computed tomography coronary angiogram (CTCA) in asymptomatic subjects. Method: We evaluated 167 asymptomatic Taiwanese subjects (mean age, 57 - 11.2 years), who underwent CTCA as part of a health evaluation.We examined the associations between FRS, CACS, serum biomarkers, and coronary plaque assessed by CTCA. Results: Out of 167 subjects in the study, 95 had coronary artery atheroma. Of those possible predictors for coronary atherosclerosis, both FRS and CACS were independent predictors for the presence of coronary plaque [relative risk (RR): 1.29, 95% confidence interval (CI): 1.07-1.54, p = 0.006 and RR: 1.42, 95% CI: 1.16-1.75, p = 0.001, respectively]. Receiver operating characteristics curve analysis revealed that CACS and FRS were indicators of the presence of coronary plaque. The area under the curve for FRS and CACS was 0.729 and 0.889, respectively (p <0.001). Furthermore, the area under the curve for combination of FRS and CACS was 0.936 (95% CI: 0.887-0.969, p <0.001), and this combination provided a better diagnostic advantage than either FRS or CACS alone (p <0.001 and p = 0.012 by C-statistic, respectively). Conclusions: In asymptomatic Taiwanese subjects with low to intermediate cardiovascular risk, both FRS and CACS were independently related to subclinical atherosclerosis. A combined FRS and CACS evaluation improved the efficacy of prediction for atherosclerotic plaque burden.

AB - Background:We sought to determine the predictive value of the combined traditional Framingham risk score (FRS) and coronary artery calcium score (CACS) for subclinical coronary plaque detected by computed tomography coronary angiogram (CTCA) in asymptomatic subjects. Method: We evaluated 167 asymptomatic Taiwanese subjects (mean age, 57 - 11.2 years), who underwent CTCA as part of a health evaluation.We examined the associations between FRS, CACS, serum biomarkers, and coronary plaque assessed by CTCA. Results: Out of 167 subjects in the study, 95 had coronary artery atheroma. Of those possible predictors for coronary atherosclerosis, both FRS and CACS were independent predictors for the presence of coronary plaque [relative risk (RR): 1.29, 95% confidence interval (CI): 1.07-1.54, p = 0.006 and RR: 1.42, 95% CI: 1.16-1.75, p = 0.001, respectively]. Receiver operating characteristics curve analysis revealed that CACS and FRS were indicators of the presence of coronary plaque. The area under the curve for FRS and CACS was 0.729 and 0.889, respectively (p <0.001). Furthermore, the area under the curve for combination of FRS and CACS was 0.936 (95% CI: 0.887-0.969, p <0.001), and this combination provided a better diagnostic advantage than either FRS or CACS alone (p <0.001 and p = 0.012 by C-statistic, respectively). Conclusions: In asymptomatic Taiwanese subjects with low to intermediate cardiovascular risk, both FRS and CACS were independently related to subclinical atherosclerosis. A combined FRS and CACS evaluation improved the efficacy of prediction for atherosclerotic plaque burden.

KW - Atherosclerosis

KW - Computed coronary tomography angiogram

KW - Coronary artery calcium score

KW - Framingham risk score

KW - Subclinical coronary plaque

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M3 - Article

VL - 29

SP - 429

EP - 435

JO - Acta Cardiologica Sinica

JF - Acta Cardiologica Sinica

SN - 1011-6842

IS - 5

ER -