Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer

Ya Ching Lu, Joseph Tung Chieh Chang, Yu Chen Huang, Chi Che Huang, Wen Ho Chen, Li Yu Lee, Bing Shen Huang, Yin Ju Chen, Hsiao Fang Li, Ann Joy Cheng

研究成果: 雜誌貢獻文章同行評審

46 引文 斯高帕斯(Scopus)

摘要

Objectives: The aim of this study was to determine whether the oncogenic microRNA family members miR-196a and miR-196b can be circulating biomarkers for the early detection of oral cancer. Design and methods: To determine the stability of circulating miRNA, the blood sample was aliquot and stored at different temperature conditions for analysis. To assess the diagnostic efficacy, we determined the levels of miR-196s in plasma samples, including 53 from healthy individuals, 16 from pre-cancer patients, and 90 from oral cancer patients. Results: In general, circulating miRNA was very stable when storing plasma samples at -20. °C or below. In clinical study, both circulating miR-196a and miR-196b were substantially up-regulated in patients with oral pre-cancer lesions (5.9- and 14.8-fold, respectively; P

原文英語
頁(從 - 到)115-121
頁數7
期刊Clinical Biochemistry
48
發行號3
DOIs
出版狀態已發佈 - 二月 1 2015
對外發佈Yes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine(all)

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