摘要
Objectives: The aim of this study was to determine whether the oncogenic microRNA family members miR-196a and miR-196b can be circulating biomarkers for the early detection of oral cancer. Design and methods: To determine the stability of circulating miRNA, the blood sample was aliquot and stored at different temperature conditions for analysis. To assess the diagnostic efficacy, we determined the levels of miR-196s in plasma samples, including 53 from healthy individuals, 16 from pre-cancer patients, and 90 from oral cancer patients. Results: In general, circulating miRNA was very stable when storing plasma samples at -20. °C or below. In clinical study, both circulating miR-196a and miR-196b were substantially up-regulated in patients with oral pre-cancer lesions (5.9- and 14.8-fold, respectively; P
原文 | 英語 |
---|---|
頁(從 - 到) | 115-121 |
頁數 | 7 |
期刊 | Clinical Biochemistry |
卷 | 48 |
發行號 | 3 |
DOIs | |
出版狀態 | 已發佈 - 2月 1 2015 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 臨床生物化學
- 醫藥 (全部)