Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks

Hsiu Ting Tsai, Ming Ju Hsieh, Chiao Wen Lin, Shih Chi Su, Nae Fang Miao, Shun Fa Yang, Hui Chuan Huang, Fu Chih Lai, Yu Fan Liu

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07∼2.31 and OR, 1.58; 95% CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65∼11.01; p = 0.002), 2.34-(95% CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95% CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
原文英語
文章編號e0163369
期刊PLoS One
12
發行號3
DOIs
出版狀態已發佈 - 三月 1 2017

指紋

Mouth Neoplasms
Polymorphism
Genes
genetic polymorphism
environmental factors
genes
Serine Proteinase Inhibitors
risk factors
Assays
gene interaction
mouth neoplasms
serine proteinases
proteinase inhibitors
breasts
Real-Time Polymerase Chain Reaction
quantitative polymerase chain reaction
Breast
assays

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

引用此文

Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks. / Tsai, Hsiu Ting; Hsieh, Ming Ju; Lin, Chiao Wen; Su, Shih Chi; Miao, Nae Fang; Yang, Shun Fa; Huang, Hui Chuan; Lai, Fu Chih; Liu, Yu Fan.

於: PLoS One, 卷 12, 編號 3, e0163369, 01.03.2017.

研究成果: 雜誌貢獻文章

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title = "Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks",
abstract = "Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95{\%} CI, 1.07∼2.31 and OR, 1.58; 95{\%} CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95{\%} CI: 1.65∼11.01; p = 0.002), 2.34-(95{\%} CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95{\%} CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.",
author = "Tsai, {Hsiu Ting} and Hsieh, {Ming Ju} and Lin, {Chiao Wen} and Su, {Shih Chi} and Miao, {Nae Fang} and Yang, {Shun Fa} and Huang, {Hui Chuan} and Lai, {Fu Chih} and Liu, {Yu Fan}",
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T1 - Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks

AU - Tsai, Hsiu Ting

AU - Hsieh, Ming Ju

AU - Lin, Chiao Wen

AU - Su, Shih Chi

AU - Miao, Nae Fang

AU - Yang, Shun Fa

AU - Huang, Hui Chuan

AU - Lai, Fu Chih

AU - Liu, Yu Fan

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07∼2.31 and OR, 1.58; 95% CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65∼11.01; p = 0.002), 2.34-(95% CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95% CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

AB - Background We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status. Methodology/Principal findings In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07∼2.31 and OR, 1.58; 95% CI, 1.04∼2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65∼11.01; p = 0.002), 2.34-(95% CI: 1.19∼4.61; p = 0.01), and 2.34-fold (95% CI: 1.38∼3.96; p = 0.001) higher risks of developing oral cancer. Conclusions Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

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