Combination chemotherapy with carmustine and cisplatin before, during, and after radiotherapy for adult malignant gliomas

Mee Chou Kiu, Chen Nen Chang, Wan Chun Cheng, Tzu Kang Lin, Cheuk Wah Wong, Simon G. Tang, Wai Man Leung, Li Hui Chen, Yet Sen Ho, Kim Thean Ng, Jen Shi Chen, Tsai Hsen Yang, Gi Ming Lai

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13 引文 斯高帕斯(Scopus)

摘要

Twenty-two patients, aged 16 to 67, who had malignant gliomas after surgical resection were treated with carmustine and cisplatin intravenous infusion before, during, and after radiotherapy. All patients had subtotal or total resection, or biopsy as the initial procedure. Twenty-one patients who had at least 2 cycles of chemotherapy and finished the whole course of radiotherapy were considered to be evaluable for responses. Among them, 5 had glioblastoma multiforme, 16 had anaplastic astrocytoma. The median time to tumor progression was 35 weeks (range 12-130 weeks) and median survival time was 66 weeks (range 10-156 weeks). Early progression occurred more frequently in patients with biopsy only and subtotal resection, and in patients with glioblastoma than in those with anaplastic astrocytoma. This combined modality treatment program was associated with reversible hematologic toxicity which was severe in 2 patients, and with ototoxicity in 1 patient, nephrotoxicity in 2 patients. Combination of carmustine and cisplatin with cranial irradiation for malignant gliomas is moderately toxic and appears to offer no obvious survival advantage compared with radiation therapy plus BCNU alone.

原文英語
頁(從 - 到)215-220
頁數6
期刊Journal of Neuro-Oncology
25
發行號3
DOIs
出版狀態已發佈 - 十月 1995
對外發佈

ASJC Scopus subject areas

  • 神經科學 (全部)
  • 腫瘤科
  • 神經病學(臨床)
  • 癌症研究

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