Cognitive Load of Exercise Influences Cognition and Neuroplasticity of Healthy Elderly: An Exploratory Investigation

Yi Ping Chao, Changwei W. Wu, Li Jung Lin, Cheng Hung Lai, Hong Yi Wu, Ai Ling Hsu, Chiao Nan Chen

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

This study explored the effects of exercise with either high cognitive load or low cognitive load on cognitive performance and neuroplasticity in healthy elderly. Twenty-eight sedentary community-dwelling seniors participated in this study. Participants were assigned to one of three groups: the control group (C), low-cognitive load exercise group (LE), or high-cognitive load exercise group (HE). Individuals in both exercise groups engaged in moderate-intensity aerobic exercise for 4 months. Resting-state functional MRI and diffusion MRI were used to investigate the effects of intervention on functional and structural connectivity, respectively. Analysis of covariance with baseline, age and the education year as covariates was used to determine the effects of intervention. We found 4 months of exercise with high-cognitive load, but not exercise with low-cognitive load, improved the overall cognitive function of healthy elderly. Additionally, the HE group showed increased resting-state functional connectivity of superior frontal gyrus and anterior cingulate cortex and decreased functional connectivity of middle occipital gyrus and postcentral gyrus. The age-related alterations in local efficiency and betweenness were protected by exercise. Our findings might suggest that exercise with greater cognitive load likely results in greater training effects on cognition and brain connectivity than exercise requiring lower cognitive loads for healthy elderly.

原文英語
頁(從 - 到)391-399
頁數9
期刊Journal of Medical and Biological Engineering
40
發行號3
DOIs
出版狀態已發佈 - 六月 1 2020

ASJC Scopus subject areas

  • 生物醫學工程

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