Cognitive impairment in fibromyalgia: A meta-analysis of case-control studies

Yu Lin Wu, Chun Jen Huang, Su Chen Fang, Ling Hsin Ko, Pei Shan Tsai

研究成果: 雜誌貢獻回顧型文獻

4 引文 (Scopus)

摘要

Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95% CI = 0.09-0.13; B = 0.02, p <.001, 95% CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.
原文英語
頁(從 - 到)432-438
頁數7
期刊Psychosomatic Medicine
80
發行號5
DOIs
出版狀態已發佈 - 六月 1 2018

指紋

Fibromyalgia
Meta-Analysis
Case-Control Studies
Cognition
Confidence Intervals
Anxiety
Depression
Neuropsychological Tests
Executive Function
Short-Term Memory
PubMed
MEDLINE
Learning
Databases
Cognitive Dysfunction

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

引用此文

Cognitive impairment in fibromyalgia : A meta-analysis of case-control studies. / Wu, Yu Lin; Huang, Chun Jen; Fang, Su Chen; Ko, Ling Hsin; Tsai, Pei Shan.

於: Psychosomatic Medicine, 卷 80, 編號 5, 01.06.2018, p. 432-438.

研究成果: 雜誌貢獻回顧型文獻

Wu, Yu Lin ; Huang, Chun Jen ; Fang, Su Chen ; Ko, Ling Hsin ; Tsai, Pei Shan. / Cognitive impairment in fibromyalgia : A meta-analysis of case-control studies. 於: Psychosomatic Medicine. 2018 ; 卷 80, 編號 5. 頁 432-438.
@article{dd2abcb3f21c49288a23a40ee073b7c1,
title = "Cognitive impairment in fibromyalgia: A meta-analysis of case-control studies",
abstract = "Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95{\%} confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95{\%} CI = 0.09-0.13; B = 0.02, p <.001, 95{\%} CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.",
keywords = "ACR = American College of Rheumatology, ACT = Auditory Consonant Trigram, BAI = Beck Anxiety Inventory, BDI = Beck Depression Inventory, BSI = Brief Symptom Inventory, Cognitive function, Fibromyalgia, Meta-analysis, Pain",
author = "Wu, {Yu Lin} and Huang, {Chun Jen} and Fang, {Su Chen} and Ko, {Ling Hsin} and Tsai, {Pei Shan}",
year = "2018",
month = "6",
day = "1",
doi = "10.1097/PSY.0000000000000575",
language = "English",
volume = "80",
pages = "432--438",
journal = "Psychosomatic Medicine",
issn = "0033-3174",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Cognitive impairment in fibromyalgia

T2 - A meta-analysis of case-control studies

AU - Wu, Yu Lin

AU - Huang, Chun Jen

AU - Fang, Su Chen

AU - Ko, Ling Hsin

AU - Tsai, Pei Shan

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95% CI = 0.09-0.13; B = 0.02, p <.001, 95% CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.

AB - Objective Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls. Methods We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017. Results Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p =.013; g = 1.22, p <.001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p <.001; g = 0.75, p <.001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p <.001, 95% CI = 0.09-0.13; B = 0.02, p <.001, 95% CI = 0.01-0.02, respectively). Conclusions Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies.

KW - ACR = American College of Rheumatology

KW - ACT = Auditory Consonant Trigram

KW - BAI = Beck Anxiety Inventory

KW - BDI = Beck Depression Inventory

KW - BSI = Brief Symptom Inventory

KW - Cognitive function

KW - Fibromyalgia

KW - Meta-analysis

KW - Pain

UR - http://www.scopus.com/inward/record.url?scp=85048710087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048710087&partnerID=8YFLogxK

U2 - 10.1097/PSY.0000000000000575

DO - 10.1097/PSY.0000000000000575

M3 - Review article

AN - SCOPUS:85048710087

VL - 80

SP - 432

EP - 438

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

IS - 5

ER -