Clinicopathologic comparisons between estrogen receptor‐positive and ‐negative gastric cancers

Chew‐Wun ‐W Wu, Shyh‐Haw ‐H Tsay, Tai‐Jay ‐J Chang, Hway‐May ‐M Chang, Mao-Chih Hsieh, Wing‐Yiu ‐Y Lui, Fang‐Ku ‐K P'Eng, Chin‐Wen ‐W Chi

研究成果: 雜誌貢獻文章

18 引文 (Scopus)

摘要

We report that a modified dextran‐coated charcoal (DCC) assay, including the addition of sodium molybdate and 5% DCC stripping of endogenous hormone, detected higher estrogen receptors (ERs) than those by the conventional assay. ERs in 21 gastric adenocarcinoma were determined by the modified DCC assay; 13 patients had ERs of 2.5 to 520.2 fmol/mg protein with a mean dissociation constant of 1.9 × 10×10 M. The remaining 8 patients had no detectable amount of the receptor. There were no differences between the ER‐positive and ER‐negative groups in clinico‐pathologic characteristics such as age, sex, tumor size, location, gross appearance, invasive depth, invasion of lymph vessel or vein of stomach wall, nodal involvement, peritoneal dissemination, liver metastasis, and curability. Histological analysis, using Japanese, Lauren's, or Ming's classifications, all revealed no differences between the ER‐positive and ‐negative groups. The survival rate was identical for the 2 study groups. These results suggest that the presence or absence of ERs in gastric adenocarcinoma does not correlate to either biologic or clinicopathologic characteristics of this tumor; the role of ERs in human gastric cancer remains to be elucidated. © 1992 Wiley‐Liss, Inc.

原文英語
頁(從 - 到)231-235
頁數5
期刊Journal of Surgical Oncology
51
發行號4
DOIs
出版狀態已發佈 - 一月 1 1992
對外發佈Yes

指紋

Estrogen Receptors
Stomach Neoplasms
Estrogens
Charcoal
Stomach
Adenocarcinoma
Lymph
Veins
Neoplasms
Survival Rate
Hormones
Neoplasm Metastasis
Liver
Proteins

ASJC Scopus subject areas

  • Surgery
  • Oncology

引用此文

Clinicopathologic comparisons between estrogen receptor‐positive and ‐negative gastric cancers. / Wu, Chew‐Wun ‐W; Tsay, Shyh‐Haw ‐H; Chang, Tai‐Jay ‐J; Chang, Hway‐May ‐M; Hsieh, Mao-Chih; Lui, Wing‐Yiu ‐Y; P'Eng, Fang‐Ku ‐K; Chi, Chin‐Wen ‐W.

於: Journal of Surgical Oncology, 卷 51, 編號 4, 01.01.1992, p. 231-235.

研究成果: 雜誌貢獻文章

Wu, CWW, Tsay, SHH, Chang, TJJ, Chang, HMM, Hsieh, M-C, Lui, WYY, P'Eng, FKK & Chi, CWW 1992, 'Clinicopathologic comparisons between estrogen receptor‐positive and ‐negative gastric cancers', Journal of Surgical Oncology, 卷 51, 編號 4, 頁 231-235. https://doi.org/10.1002/jso.2930510406
Wu, Chew‐Wun ‐W ; Tsay, Shyh‐Haw ‐H ; Chang, Tai‐Jay ‐J ; Chang, Hway‐May ‐M ; Hsieh, Mao-Chih ; Lui, Wing‐Yiu ‐Y ; P'Eng, Fang‐Ku ‐K ; Chi, Chin‐Wen ‐W. / Clinicopathologic comparisons between estrogen receptor‐positive and ‐negative gastric cancers. 於: Journal of Surgical Oncology. 1992 ; 卷 51, 編號 4. 頁 231-235.
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