Clinicopathologic analysis of coxsackievirus A6 new variant induced widespread mucocutaneous bullous reactions mimicking severe cutaneous adverse reactions

Wen Hung Chung, Shin Ru Shih, Ching Fen Chang, Tzou Yien Lin, Yhu Chering Huang, Shih Chen Chang, Ming Tsan Liu, Yu Shien Ko, Ming Chung Deng, Yea Ling Liau, Lung Huang Lin, Tou Hwei Chen, Chih Hsun Yang, Hsin Chun Ho, Jheng Wei Lin, Chun Wei Lu, Chin Fang Lu, Shuen Lu Hung

研究成果: 雜誌貢獻文章同行評審

53 引文 斯高帕斯(Scopus)

摘要

Background. The cutaneous manifestations of human enterovirus (HEV) infection are usually limited, such as hand-foot-mouth disease. By comparison, Stevens-Johnson syndrome (SJS) is a life-threatening severe cutaneous adverse reaction (SCAR), mainly caused by drugs. During the HEV outbreaks in 2010-2012 in Taiwan, we identified 21 patients who developed widespread blistering mucocutaneous reactions without any suspected drug causality. Methods. We screened possible pathogen(s) for detecting human herpes virus (HHV1-HHV7), HEV, or Mycoplasma pneumoniae infections using throat swab virus cultures, real-time PCR, DNA sequencing, immunochemis-try and electron microscopy analyses. Results. Coxsackievirus A6 (CVA6) DNA was identified in the blistering skin lesions in 6 of 21 patients. Cytotoxic T lymphocytes and natural killer cells expressing granulysin predominantly infiltrated into the skin lesions, sharing the histopathological features with SJS. Intact CVA6 viral particles were identified in the blister fluids and skin lesions by electron microscopy. The phylogenetic analysis of the viral genome showed the CVA6 DNA sequence sharing higher similarity (97.6%-98.1%) to CVA6 strains reported from Finland at 2008. Conclusions. This study identifies a new variant of CVA6 as the causative agent for severe mucocutaneous blistering reactions mimicking SCAR. An awareness of this unusual presentation of HEV infection is needed in the epidemic area.
原文英語
頁(從 - 到)1968-1978
頁數11
期刊Journal of Infectious Diseases
208
發行號12
DOIs
出版狀態已發佈 - 十二月 15 2013
對外發佈

ASJC Scopus subject areas

  • 傳染性疾病
  • 免疫學和過敏
  • 醫藥 (全部)

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