Clinical use of single-dose surfactant TA therapy for premature infants with severe respiratory distress syndrome.

H. H. Deng, M. C. Kuo, K. H. Chung, Hsun-Hui Hsu, S. T. Lin

研究成果: 雜誌貢獻文章同行評審

摘要

A single dose of surfactant TA was given as rescue therapy to four small premature infants with severe respiratory distress syndrome requiring mechanical ventilation. Birth weights ranged from 810 to 1200 gm. The dose of 100-120 mg/kg was given at the mean age of 5 hours, with range of 3 to 7 hours. Following surfactant therapy, there was a significant improvement (p <0.05) in a/APO2 (raising from 0.11 +/- 0.05 before treatment to 0.34 +/- 0.19 at 6 hours after treatment). There was also a significant reduction in the severity of respiratory distress syndrome at 24 hours post-therapy. One baby died of sepsis at 40 hours of life; one survived without complications. The other two cases developed severe bronchopulmonary dysplasia later. We concluded that early use of exogenous surfactant is beneficial in small premature infants with severe respiratory distress syndrome.
原文英語
頁(從 - 到)408-416
頁數9
期刊Acta Paediatrica Sinica
33
發行號6
出版狀態已發佈 - 十一月 1992

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康

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