Clinical implication of perioperative inflammatory cytokine alteration

Chung-Hsi Hsing, Jhi Joung Wang

研究成果: 雜誌貢獻回顧型文獻同行評審

31 引文 斯高帕斯(Scopus)

摘要

Cytokines are key modulators of inflammatory responses, and play an important role in the defense and repair mechanisms following trauma. After traumatic injury, an immuno-inflammatory response is initiated immediately, and cytokines rapidly appear and function as a regulator of immunity. In pathologic conditions, imbalanced cytokines may provide systemic inflammatory responses or immunosuppression. Expression of perioperative cytokines vary by different intensities of surgical trauma and types of anesthesia and anesthetic agents. Inflammatory cytokines play important roles in postoperative organ dysfunction including central nervous system, cardiovascular, lung, liver, and kidney injury. Inhibition of cytokines could protect against traumatic injury in some circumstances, therefore cytokine inhibitors or antagonists might have the potential for reducing postoperative tissue/organ dysfunction. Cytokines are also involved in wound healing and post-traumatic pain. Application of cytokines for the improvement of surgical wound healing has been reported. Anesthesia-related immune response adjustment might reduce perioperative morbidity because it reduces proinflammatory cytokine expression; however, the overall effects of anesthetics on postoperative immune-inflammatory responses needs to be further investigated.

原文英語
頁(從 - 到)23-28
頁數6
期刊Acta Anaesthesiologica Taiwanica
53
發行號1
DOIs
出版狀態已發佈 - 三月 1 2015

ASJC Scopus subject areas

  • 麻醉與疼痛醫學

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